Epirubicin-sensitive detection with a CoWO/reduced graphene oxide modified screen-printed electrode.

BACKGROUND AND PURPOSE

Because of its antimetabolic and cytotoxic qualities, epirubicin (EP), a crucial chemotherapeutic drug, has been used to treat a number of cancers, including those of the prostate, breast, ovary, stomach, lung, and colon.

EXPERIMENTAL APPROACH

In this study, CoWO/reduced graphene oxide (CoWO/rGO) nanocomposite was synthesised and characterised by field emission-scanning electron microscopy and energy-dispersive X-ray spectroscopy. To provide a novel sensing platform for EP determination, a screen-printed electrode (SPE) surface was modified using the as-fabricated CoWO/rGO nanocomposite.

KEY RESULTS

Using voltammetric techniques, the electrochemical behaviour of the CoWO/rGO nanocomposite modified SPE (CoWO/rGO/SPE) for the EP detection was examined. CoWO/rGO significantly reduced the overpotential of the EP redox reaction and increased the rate of electron transfer between the electrode and analyte as compared to bare SPE. EP was quantitatively analysed using differential pulse voltammetry.

CONCLUSIONS

It was discovered that the linearity range was 0.01 to 190.0 μM. The sensitivity and limit of detection were 0.1529 μA μM and 0.007 μM, respectively. Additionally, the constructed CoWO/rGO/SPE sensor's practical applicability was investigated in pharmaceutical samples with good recovery outcomes.