Too Yuan-Xian, Hsiao Chen-Yu, Chen Tai-Jui
Department of Diagnostic Radiology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, TWN.
Cureus. 2025 May 30;17(5):e85068. doi: 10.7759/cureus.85068. eCollection 2025 May.
Calcified chondroid mesenchymal neoplasm (CCMN) is a rare, recently defined tumor characterized by mesenchymal tissue with chondroid features and calcification. It typically harbors an FN1 fusion and shows a predilection for the temporomandibular joint and distal extremities. CCMN is benign and has not been associated with malignant behavior. We present the case of a 61-year-old woman with an eight-year history of a progressively enlarging, palpable mass in the left parotid region, associated with ipsilateral hearing loss and facial palsy. Imaging studies, including computed tomography (CT) and magnetic resonance imaging (MRI), revealed a well-defined tumor located between the left masseter muscle and parotid gland, extending into the left supratemporal fossa. The lesion exhibited heterogeneous soft tissue density with irregular intratumoral calcifications and moderate contrast enhancement. Ultrasound demonstrated a hypo- to isoechoic nodular lesion within the left parotid gland. Histopathological evaluation, in correlation with imaging findings, confirmed the diagnosis of CCMN. Surgical excision was performed, and postoperative imaging showed no residual tumor. This case highlights the importance of considering CCMN in the differential diagnosis of calcified soft tissue tumors in the head and neck region.
钙化性软骨样间叶肿瘤（CCMN）是一种罕见的、最近才定义的肿瘤，其特征是具有软骨样特征和钙化的间叶组织。它通常存在FN1融合，并且好发于颞下颌关节和四肢远端。CCMN是良性的，与恶性行为无关。我们报告一例61岁女性病例，其左侧腮腺区有一个逐渐增大、可触及的肿块，病史长达8年，伴有同侧听力丧失和面神经麻痹。包括计算机断层扫描（CT）和磁共振成像（MRI）在内的影像学检查显示，在左咬肌和腮腺之间有一个边界清晰的肿瘤，延伸至左颞上窝。该病变表现为不均匀的软组织密度，伴有不规则的瘤内钙化和中度强化。超声显示左侧腮腺内有一个低回声至等回声的结节性病变。组织病理学评估结合影像学表现，确诊为CCMN。进行了手术切除，术后影像学检查显示无残留肿瘤。该病例强调了在头颈部钙化性软组织肿瘤的鉴别诊断中考虑CCMN的重要性。
