Hayashi Arisa, Ukai Mika, Kanda Shoichiro, Takizawa Keiichi, Kinumaki Akiko
Pediatrics, The University of Tokyo, Tokyo, JPN.
Cureus. 2025 May 28;17(5):e84946. doi: 10.7759/cureus.84946. eCollection 2025 May.
Rotavirus infection is a common cause of pediatric gastroenteritis, often self-limited but occasionally associated with extraintestinal complications. This report describes a 12-year-old vaccinated girl who presented with acute gastroenteritis and an incidental elevation of serum creatine kinase (CK). Despite the absence of muscle pain or weakness during hospitalization, laboratory findings indicated skeletal muscle involvement, with elevated CK and aldolase levels, and a predominance of CK-MM isoenzyme. Myocardial involvement and rhabdomyolysis were ruled out. The patient recovered with supportive care, and CK levels normalized after discharge, although she reported mild post-discharge fatigue. Rotavirus-associated myositis is rare and likely underrecognized, particularly in young children who may not verbalize muscle symptoms. This case highlights the importance of considering myositis in patients with elevated CK during rotavirus infection, even in the absence of overt muscular symptoms.
轮状病毒感染是小儿肠胃炎的常见病因，通常为自限性，但偶尔会伴有肠外并发症。本报告描述了一名12岁接种过疫苗的女孩，她因急性肠胃炎就诊，血清肌酸激酶（CK）意外升高。尽管住院期间没有肌肉疼痛或无力症状，但实验室检查结果表明存在骨骼肌受累，CK和醛缩酶水平升高，且以CK-MM同工酶为主。排除了心肌受累和横纹肌溶解症。患者通过支持治疗康复，出院后CK水平恢复正常，不过她自述出院后有轻度疲劳。轮状病毒相关性肌炎罕见，可能未得到充分认识，尤其是在可能无法表达肌肉症状的幼儿中。该病例强调了在轮状病毒感染期间CK升高的患者中考虑肌炎的重要性，即使没有明显的肌肉症状。
