Simões Raposo Leonor, Pacheco Andreia, Mendes Maria
General Practice, Family Unit Conde de Oeiras, Western Lisbon Local Health Unit, Lisbon, PRT.
Family Medicine, Family Unit Conde de Oeiras, Western Lisbon Local Health Unit, Lisbon, PRT.
Cureus. 2025 May 30;17(5):e85088. doi: 10.7759/cureus.85088. eCollection 2025 May.
Pernicious anemia is an infrequent condition and a recognized cause of vitamin B12 deficiency. It is an autoimmune disease that impairs the absorption of vitamin B12, leading to a significant reduction in its uptake. Clinical manifestations are often subtle and non-specific, yet potentially debilitating, which may delay diagnosis. However, with early recognition in primary care and appropriate replacement therapy, patients can recover their quality of life. Fatigue and asthenia are common complaints in primary care, highlighting the importance of careful clinical evaluation in the presence of nonspecific symptoms. Timely laboratory investigations are essential for the early detection of the disease and the prevention of serious complications.
恶性贫血是一种罕见的疾病，也是维生素B12缺乏的一个公认原因。它是一种自身免疫性疾病，会损害维生素B12的吸收，导致其摄取量显著减少。临床表现往往不明显且不具特异性，但可能使人衰弱，这可能会延迟诊断。然而，通过初级保健中的早期识别和适当的替代疗法，患者可以恢复生活质量。疲劳和乏力是初级保健中常见的主诉，这凸显了在出现非特异性症状时进行仔细临床评估的重要性。及时进行实验室检查对于疾病的早期检测和严重并发症的预防至关重要。
