Kloss R, Keller H E, Stober T, Emde H, Schimrigk K
Nervenarzt. 1985 Aug;56(8):417-22.
There are conflicting reports of an increase in the activity of creatine kinase BB isoenzyme (CK-BB) in the serum of patients with cerebrovascular disease. The serum CK-BB activity of 33 patients with ischemic brain infarction, subarachnoid hemorrhage or intracerebral hemorrhage was measured with a bioluminescence method (CK-B Kit, LKB-Wallac) in combination with immunoprecipitation. The results were compared with lesions determined by computed tomography. In the control group (N = 19) there was a mean activity of 0.35 +/- 0.26 U/l (means +/- SE). In patients with small lesions (N = 11) the activity was 0.41 +/- 0.21 U/l, which was not significantly elevated when compared to the control group (Mann/Whitney U test). Therefore, patients with more extensive lesions (N = 12) and the group with severe lesions (N = 10) showed a significant elevation, with a mean activity of 0.61 +/- 0.34 U/l and 1.12 +/- 0.52 U/l, respectively. The group with severe lesions had a maximum activity on the first day after the initial symptoms.
关于脑血管疾病患者血清中肌酸激酶BB同工酶（CK - BB）活性增加的报道相互矛盾。采用生物发光法（CK - B试剂盒，LKB - Wallac）结合免疫沉淀法，测定了33例缺血性脑梗死、蛛网膜下腔出血或脑出血患者的血清CK - BB活性。将结果与计算机断层扫描确定的病变进行比较。在对照组（N = 19）中，平均活性为0.35±0.26 U/l（均值±标准误）。小病变患者（N = 11）的活性为0.41±0.21 U/l，与对照组相比无显著升高（曼 - 惠特尼U检验）。因此，病变范围更广的患者（N = 12）和严重病变组（N = 10）的活性显著升高，平均活性分别为0.61±0.34 U/l和1.12±0.52 U/l。严重病变组在初始症状出现后的第一天活性最高。
