Wu Hong, Wu Jia-Yi, Gao Shao-Jie, Liu Lin, Dai Xin-Yi, Song Wen-Lu, Zhang Long-Qing, Liu Dai-Qiang, Tang Ying-Xin, Zhou Ya-Qun, Mei Wei
Department of Anesthesiology and Pain Medicine, Hubei Key Laboratory of Geriatric Anesthesia and Perioperative Brain Health, and Wuhan Clinical Research Center of Geriatric Anesthesia, Tongji hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Aging Dis. 2025 Jun 23. doi: 10.14336/AD.2025.0530.
Resveratrol, a natural polyphenol with anti-inflammatory, antioxidant, and neuroprotective properties, shows great potential in managing chronic pain. This review explores its analgesic mechanisms, including the inhibition of neuroinflammation, enhancement of antioxidant activity, induction of autophagy, reduction of endoplasmic reticulum stress, modulation of the serotonin system, restoration of gut microbiota homeostasis, regulation of the neuroendocrine system, and promotion of mitochondrial biogenesis. While its analgesic potential is considerable, future research should prioritize enhancing its bioavailability, investigating drug interactions, and confirming long-term safety to develop more effective therapies for chronic pain.
白藜芦醇是一种具有抗炎、抗氧化和神经保护特性的天然多酚，在慢性疼痛管理方面具有巨大潜力。本综述探讨了其镇痛机制，包括抑制神经炎症、增强抗氧化活性、诱导自噬、减轻内质网应激、调节血清素系统、恢复肠道微生物群稳态、调节神经内分泌系统以及促进线粒体生物发生。尽管其镇痛潜力可观，但未来研究应优先提高其生物利用度、研究药物相互作用并确认长期安全性，以开发更有效的慢性疼痛治疗方法。
