Anger W K
Neurobehav Toxicol Teratol. 1985 Jul-Aug;7(4):359-68.
Between 1973 and 1983, the National Institute for Occupational Safety and Health (NIOSH) published 11 studies which reported the neurobehavioral effects of chronic exposures to industrial chemicals among working groups. This paper reviews the objectives, testing methods, findings and conclusions of these studies. The studies employed a single rationale for selecting tests--tests sensitive to the types of effects reported for the chemical under study were utilized in each case. As a result, different sets of tests were used for different studies. This strategy is distinct from the approach suggested in the other reports in these proceedings which advocate the use of a uniform test battery. The wide variety of neurobehavioral effects produced by chemicals found in the environment argues for a rationale of tailoring test selection in many situations, particularly those where the range of expected effects has been fairly well established for the chemical under study.
1973年至1983年间,美国国家职业安全与健康研究所(NIOSH)发表了11项研究,报告了工作组中慢性接触工业化学品的神经行为影响。本文回顾了这些研究的目标、测试方法、结果和结论。这些研究采用了单一的测试选择原理——每种情况下都使用对所研究化学品报告的影响类型敏感的测试。因此,不同的研究使用了不同的测试集。这种策略与本会议其他报告中建议的方法不同,那些报告主张使用统一的测试组。环境中发现的化学品产生的多种神经行为影响表明,在许多情况下,特别是那些对所研究化学品的预期影响范围已经相当明确的情况下,有必要采用量身定制测试选择的原理。