苯妥英对低钙溶液中大鼠海马切片场电位爆发的影响。

Effects of phenytoin on field bursts of rat hippocampal slices in low-calcium solutions.

作者信息

Snow R W, Hasan Z, Dudek F E

出版信息

Neuropharmacology. 1985 Sep;24(9):915-7. doi: 10.1016/0028-3908(85)90045-0.

Abstract

Recurring bursts of population spikes, a simple model of epileptiform activity, can be produced by exposing slices of rat hippocampus to saline containing 0.2 mM [Ca2+] and 4.0 mM [Mg2+], at which concentration chemical synaptic activity is blocked. Phenytoin at 7.3-73 microM shortened the duration of these bursts. At 73 microM the bursts were slowed and often eliminated. This model appears to be more sensitive to the action of phenytoin than the penicillin model of epileptiform bursting.

摘要

反复出现的群体尖峰放电，一种癫痫样活动的简单模型，可以通过将大鼠海马切片暴露于含有0.2 mM [Ca2+]和4.0 mM [Mg2+]的盐溶液中产生，在此浓度下化学突触活动被阻断。7.3 - 73 microM的苯妥英缩短了这些爆发的持续时间。在73 microM时，爆发减慢且常常被消除。该模型似乎比癫痫样爆发的青霉素模型对苯妥英的作用更敏感。