Ropper A H, Kehne S M
Neurology. 1985 Nov;35(11):1662-5. doi: 10.1212/wnl.35.11.1662.
Nineteen of 38 consecutive patients with Guillain-Barré syndrome were treated with mechanical ventilation in a neurological ICU. A ventilator was used for expiratory vital capacity (VC) below 12 to 15 ml/kg or arterial PO2 below 70 mm Hg, or clinical signs of fatigue. Artificial ventilation was discontinued when VC reached 8 to 10 ml/kg. Twelve patients required tracheostomy at 11 days (mean) after intubation. Mechanical ventilation was required for 49 days (mean). Complications included pneumonia in 15 patients, mostly aspiration, only 1 severe; pulmonary embolus in 1 ventilated and 1 nonventilated patient; and tracheal stenosis in 1. There was one death in a previously unintubated patient who developed sepsis while improving from GBS, and no deaths in the 18 other intubated patients.
38例连续性格林-巴利综合征患者中有19例在神经重症监护病房接受了机械通气治疗。当呼气肺活量（VC）低于12至15 ml/kg或动脉血氧分压低于70 mmHg，或出现疲劳的临床体征时，使用呼吸机。当VC达到8至10 ml/kg时，停止人工通气。12例患者在插管后11天（平均）需要行气管切开术。机械通气平均需要49天。并发症包括15例患者发生肺炎，多数为误吸，仅1例严重；1例接受机械通气患者和1例未接受机械通气患者发生肺栓塞；1例发生气管狭窄。1例先前未插管的患者在从格林-巴利综合征病情改善过程中发生脓毒症死亡，其他18例插管患者无死亡。
