Hu Xin-Yue, Chen Guang-Lei, Yang Xiao-Fang, Zhang Ning
School of Acupuncture and Tuina, Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou, China.
School of Basic Medicine, Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou, China.
Medicine (Baltimore). 2025 Jun 27;104(26):e42859. doi: 10.1097/MD.0000000000042859.
Employing a bidirectional 2-sample Mendelian Randomization (MR) approach, this study endeavors to assess the potential causal relationship between attention deficit hyperactivity disorder (ADHD) and atherosclerosis (AS). Single nucleotide polymorphism loci, associated with ADHD at a significant threshold (P < 5 × 10-8), were meticulously screened from genome-wide association studies datasets to serve as instrumental variables. The primary outcomes under investigation encompass AS, coronary atherosclerosis, and cerebral atherosclerosis. Employing inverse variance weighted method (IVW), MR-Egger regression, weighted median method, simple mode and weighted mode, MR analyses were executed to systematically evaluate the causal relationships between ADHD and AS, coronary atherosclerosis, and cerebral atherosclerosis. The MR analysis reveals a positive and statistically significant causal relationship between ADHD and AS (OR = 1.167, 95% CI = 1.003-1.359, P = .046). Notably, no discernible causal links were identified between ADHD and coronary atherosclerosis or cerebral atherosclerosis. Furthermore, there is a lack of evidence supporting an augmented risk of AS, coronary atherosclerosis, or cerebral atherosclerosis associated with ADHD. Through MR analysis, it was found that ADHD increases the risk of AS. However, no causal association has been identified in studies and reverse studies investigating the relationship between ADHD and both coronary atherosclerosis and cerebral atherosclerosis. Therefore, while ADHD may elevate the susceptibility to AS, further investigations are warranted to clarify the exact nature of this association.
本研究采用双向两样本孟德尔随机化（MR）方法，旨在评估注意力缺陷多动障碍（ADHD）与动脉粥样硬化（AS）之间的潜在因果关系。从全基因组关联研究数据集中精心筛选出与ADHD显著相关（P<5×10-8）的单核苷酸多态性位点作为工具变量。研究的主要结局包括AS、冠状动脉粥样硬化和脑动脉粥样硬化。采用逆方差加权法（IVW）、MR-Egger回归、加权中位数法、简单模式和加权模式，进行MR分析以系统评估ADHD与AS、冠状动脉粥样硬化和脑动脉粥样硬化之间的因果关系。MR分析显示ADHD与AS之间存在正向且具有统计学意义的因果关系（OR=1.167，95%CI=1.003-1.359，P=0.046）。值得注意的是，未发现ADHD与冠状动脉粥样硬化或脑动脉粥样硬化之间存在明显的因果联系。此外，缺乏证据支持ADHD会增加AS、冠状动脉粥样硬化或脑动脉粥样硬化的风险。通过MR分析发现，ADHD会增加AS的风险。然而，在研究以及关于ADHD与冠状动脉粥样硬化和脑动脉粥样硬化关系的反向研究中均未发现因果关联。因此，虽然ADHD可能会增加患AS的易感性，但仍需要进一步研究以阐明这种关联的确切性质。
