Department of Epidemiology.
Center for Disabilities and Development.
Health Psychol. 2022 Oct;41(10):693-700. doi: 10.1037/hea0001193. Epub 2022 Jul 18.
To examine the association between attention-deficit/hyperactivity disorder (ADHD) and cardiovascular disease (CVD) in a nationally representative population sample of adults in the United States.
We included adults aged 18 years or older who participated in the National Health Interview Survey 2007 and 2012, because information about ADHD diagnosis among adults was only available in these two cycles. Physician-diagnosed ADHD and CVD were defined based on an affirmative response in the questionnaire during a household interview. Logistic regression with survey sampling weights was used to estimate the odds ratio () and 95% confidence intervals (CIs) of CVD.
This analysis included 57,728 adults (weighted mean age 46.20 years; 47.66% males). Among them, 1,790 reported physician-diagnosed ADHD, 7,906 had CVD, 4,061 had coronary heart disease (CHD), and 1,749 had stroke. The age-adjusted prevalence of CVD was 19.72% (95% CI [16.56%, 22.88%]) among individuals with ADHD, and 12.09% (95% CI [11.75%, 12.43%]) among those without ADHD. After adjustment for age, sex, race/ethnicity, education level, family income level, smoking, alcohol drinking, physical activity, and body mass index, the OR of CVD, CHD and stroke in association with ADHD was 2.06 (95% CI [1.58, 2.68]), 1.88 (95% CI [1.31, 2.69]), and 1.75 (95% CI [1.07, 2.86]), respectively.
In a nationally representative sample of U.S. adults, we found a significant, positive association between a history of ADHD diagnosis and CVD. Further investigation is needed to replicate our findings and determine the underlying mechanisms. (PsycInfo Database Record (c) 2022 APA, all rights reserved).
在美国全国代表性的成年人人群样本中，研究注意力缺陷/多动障碍（ADHD）与心血管疾病（CVD）之间的关联。
我们纳入了年龄在 18 岁及以上的参加了 2007 年和 2012 年全国健康访谈调查的成年人，因为只有在这两个周期中才有关于成年人 ADHD 诊断的信息。医生诊断的 ADHD 和 CVD 是根据家庭访谈中问卷的肯定回答来定义的。采用具有调查抽样权重的 logistic 回归来估计 CVD 的比值比（OR）和 95%置信区间（CI）。
本分析包括 57728 名成年人（加权平均年龄 46.20 岁；47.66%为男性）。其中，1790 人报告有医生诊断的 ADHD，7906 人有 CVD，4061 人有冠心病（CHD），1749 人有中风。患有 ADHD 的个体的 CVD 年龄调整患病率为 19.72%（95%CI [16.56%，22.88%]），而没有 ADHD 的个体为 12.09%（95%CI [11.75%，12.43%]）。在调整年龄、性别、种族/民族、教育水平、家庭收入水平、吸烟、饮酒、身体活动和体重指数后，ADHD 与 CVD、CHD 和中风相关的 OR 分别为 2.06（95%CI [1.58，2.68]）、1.88（95%CI [1.31，2.69]）和 1.75（95%CI [1.07，2.86]）。
在一个具有美国全国代表性的成年人样本中，我们发现 ADHD 诊断史与 CVD 之间存在显著的正相关关系。需要进一步的研究来复制我们的发现并确定潜在的机制。
