A molecular tango between chromatin and metabolites orchestrates a feedback switch for alcohol consumption.
作者信息
Schmidt Heidi M, Tarling Elizabeth J, Vallim Thomas Q de Aguiar
机构信息
Division of Cardiology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095.
Jonsson Comprehensive Cancer Center, University of California, Los Angeles, CA 90095.
出版信息
Proc Natl Acad Sci U S A. 2025 Jul 8;122(27):e2512733122. doi: 10.1073/pnas.2512733122. Epub 2025 Jun 30.
Abstract
摘要
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FGF21 counteracts alcohol intoxication by activating the noradrenergic nervous system.FGF21 通过激活去甲肾上腺素能神经系统来对抗酒精中毒。
Cell Metab. 2023 Mar 7;35(3):429-437.e5. doi: 10.1016/j.cmet.2023.02.005.
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FGF21 suppresses alcohol consumption through an amygdalo-striatal circuit.FGF21 通过杏仁核-纹状体回路抑制酒精摄入。
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Liver Derived FGF21 Maintains Core Body Temperature During Acute Cold Exposure.肝脏来源的成纤维细胞生长因子 21 在急性冷暴露期间维持核心体温。
Sci Rep. 2019 Jan 24;9(1):630. doi: 10.1038/s41598-018-37198-y.
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Fibroblast Growth Factor 21: A Versatile Regulator of Metabolic Homeostasis.成纤维细胞生长因子 21：代谢稳态的多功能调节剂。
Annu Rev Nutr. 2018 Aug 21;38:173-196. doi: 10.1146/annurev-nutr-071816-064800. Epub 2018 May 4.
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FGF21 Regulates Sweet and Alcohol Preference.成纤维细胞生长因子21调节对甜味和酒精的偏好。
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FGF21 Mediates Endocrine Control of Simple Sugar Intake and Sweet Taste Preference by the Liver.成纤维细胞生长因子21介导肝脏对单糖摄入和甜味偏好的内分泌控制。
Cell Metab. 2016 Feb 9;23(2):335-43. doi: 10.1016/j.cmet.2015.12.003. Epub 2015 Dec 24.
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Novel role for carbohydrate responsive element binding protein in the control of ethanol metabolism and susceptibility to binge drinking.碳水化合物反应元件结合蛋白在控制乙醇代谢和 binge drinking 易感性中的新作用。
Hepatology. 2015 Oct;62(4):1086-100. doi: 10.1002/hep.27778. Epub 2015 May 6.
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FGF21 maintains glucose homeostasis by mediating the cross talk between liver and brain during prolonged fasting.FGF21 通过在长时间禁食期间介导肝脏和大脑之间的串扰来维持葡萄糖稳态。
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