Fleischman Debra A, Arfanakis Konstantinos, Leurgans Sue E, Evia Arnold M, Lamar Melissa, Kapasi Alifiya, Han S Duke, Poole Victoria N, Wagner Maude, Bennett David A, Barnes Lisa L
Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA.
Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA.
Alzheimers Dement. 2025 Jul;21(7):e70430. doi: 10.1002/alz.70430.
ARTS, an in vivo marker of cerebral arteriolosclerosis, may identify older individuals at risk of mild cognitive impairment (MCI), dementia, and stroke due to cerebral small vessel disease, but deeper characterization in a large, diverse sample is needed.
Associations between ARTS and incident MCI, dementia, and stroke, and with several common vascular risk factors, were examined in 1226 older adults without dementia and within White (n = 707), Black (n = 400), and Latino (n = 110) subgroups.
Higher ARTS score was associated (all ps < 0.01) with incident MCI (hazard ratio [HR] = 1.29), dementia (HR = 1.33), and stroke (HR = 1.52) and with diastolic/systolic blood pressure, self-reported hypertension, claudication, congestive heart failure, smoking, and glomerular filtration rate in the combined sample. Results varied across racial and ethnic groups.
ARTS has utility as an in vivo marker of cerebral arteriolosclerosis and risk of MCI, dementia, and stroke.
ARTS score, an in vivo marker of cerebral arteriolosclerosis, was associated with incident mild cognitive impairment (MCI), dementia, and stroke in a diverse sample. ARTS score was associated with incident dementia in the non-Latino (NL) White and NL Black subgroups separately. ARTS score was associated with incident MCI in the NL Black subgroup. Common vascular risk factors were associated with ARTS score, consistent with ex vivo studies. ARTS has utility as a marker for the risk of MCI, dementia, and stroke.
ARTS作为脑小动脉硬化的一种体内标志物，可能有助于识别有轻度认知障碍（MCI）、痴呆症以及因脑小血管疾病引发中风风险的老年人，但需要在一个大规模、多样化的样本中进行更深入的特征分析。
在1226名无痴呆症的老年人以及白人（n = 707）、黑人（n = 400）和拉丁裔（n = 110）亚组中，研究了ARTS与新发MCI、痴呆症和中风之间的关联，以及与几种常见血管危险因素的关联。
在综合样本中，较高的ARTS评分与新发MCI（风险比[HR]=1.29）、痴呆症（HR = 1.33）和中风（HR = 1.52）以及舒张压/收缩压、自我报告的高血压、间歇性跛行、充血性心力衰竭、吸烟和肾小球滤过率相关（所有p值<0.01）。不同种族和族裔群体的结果有所不同。
ARTS可作为脑小动脉硬化以及MCI、痴呆症和中风风险的体内标志物。
ARTS评分作为脑小动脉硬化的体内标志物，在一个多样化样本中与新发轻度认知障碍（MCI）、痴呆症和中风相关。ARTS评分分别与非拉丁裔（NL）白人亚组和NL黑人亚组中的新发痴呆症相关。ARTS评分与NL黑人亚组中的新发MCI相关。常见血管危险因素与ARTS评分相关，这与体外研究一致。ARTS可作为MCI、痴呆症和中风风险的标志物。
