The aim of the study was to identify the efficacy of platelet rich plasma plus nano fat therapy in comparison to nano fat therapy alone on burn scars. The study was conducted at the Department of Plastic & Reconstructive Surgery Dr. Ruth KM Pfau, Civil Hospital Karachi, Dow University of Health Sciences Pakistan from March 2021 to February 2022. Sixty-four patients with mature burn scar of both genders aged eighteen and above were included and randomly distributed in 2 groups: one group received treatment with nano fat therapy whereas the other group received treatment with nano fat therapy and platelet rich plasma. Vancouver scar scale (VSS) score was used to assess the scar at baseline, 1 month, 3 months and finally after 6 months. For both groups, the highest mean total VSS score values were observed at baseline and lowest at 6 months. All mean values at various points for the PRP + nano fat group were lower than mean values for the nano fat group. However, the mean difference between the two groups for scores after 6 months was insignificant. It was concluded that results of both treatments are equivocal.