脂肪来源的基质血管成分细胞和富血小板血浆：面部瘢痕患者基于细胞治疗的基础与临床评估
Adipose-derived stromal vascular fraction cells and platelet-rich plasma: basic and clinical evaluation for cell-based therapies in patients with scars on the face.
作者信息
Gentile Pietro, De Angelis Barbara, Pasin Methap, Cervelli Giulio, Curcio Cristiano B, Floris Micol, Di Pasquali Camilla, Bocchini Ilaria, Balzani Alberto, Nicoli Fabio, Insalaco Chiara, Tati Eleonora, Lucarini Lucilla, Palla Ludovico, Pascali Michele, De Logu Pamela, Di Segni Chiara, Bottini Davide J, Cervelli Valerio
机构信息
From the *Department of Plastic and Reconstructive Surgery, University of Rome Tor Vergata; †Department of Immunohematology and Transfusion, Casilino Hospital; and ‡Department of Education, University of Rome Tor Vergata, Rome, Italy.
出版信息
J Craniofac Surg. 2014 Jan;25(1):267-72. doi: 10.1097/01.scs.0000436746.21031.ba.
BACKGROUND
Actually, autologous fat grafts have many clinical applications in breast surgery, facial rejuvenation, buttock augmentation, and Romberg syndrome as well as a treatment of liposuction sequelae.
OBJECTIVE
The aim of this article was to describe the preparation and isolation procedures for stromal vascular fraction (SVF), the preparation of platelet-rich plasma (PRP), and the clinical application in the treatment of the scar on the face.
METHODS
Ten patients with burns sequelae (n = 6) and post-traumatic scars (n = 4) were treated with SVF-enhanced autologous fat grafts obtained by the Celution System. Another 10 patients with burns sequelae (n = 5) and post-traumatic scars (n = 5) were treated with fat grafting based on the Coleman technique mixed with 0.5 mL of PRP.To assess the effects of their treatment, the authors compared their results with those of a control group consisting of 10 patients treated with centrifuged fat.
RESULTS
In the patients treated with SVF-enhanced autologous fat grafts, we observed a 63% maintenance of contour restoring after 1 year compared with only 39% of the control group (n = 10) treated with centrifuged fat graft (P < 0.0001). In the patients treated with fat grafting and PRP, we observed a 69% maintenance of contour restoring after 1 year compared with that of the control group (n = 10).
CONCLUSIONS
Autologous fat grafting is a good method for the correction of scars on the face instead of the traditional scar surgical excision.
背景
实际上，自体脂肪移植在乳房手术、面部年轻化、臀部增大、Romberg综合征以及抽脂后遗症治疗等方面有许多临床应用。
目的
本文旨在描述基质血管成分（SVF）的制备和分离程序、富血小板血浆（PRP）的制备以及其在面部瘢痕治疗中的临床应用。
方法
10例烧伤后遗症患者（n = 6）和创伤后瘢痕患者（n = 4）接受了通过Celution系统获得的SVF增强自体脂肪移植治疗。另外10例烧伤后遗症患者（n = 5）和创伤后瘢痕患者（n = 5）接受了基于Coleman技术并混合0.5 mL PRP的脂肪移植治疗。为评估治疗效果，作者将结果与由10例接受离心脂肪治疗的患者组成的对照组进行比较。
结果
接受SVF增强自体脂肪移植治疗的患者，1年后观察到轮廓恢复维持率为63%，而接受离心脂肪移植治疗的对照组（n = 10）仅为39%（P < 0.0001）。接受脂肪移植和PRP治疗的患者，1年后观察到轮廓恢复维持率为69%，与对照组（n = 10）相比。
结论
自体脂肪移植是治疗面部瘢痕的一种良好方法，而非传统的瘢痕手术切除。
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