Li Xiaying, Zhang Hengkai, Zhou Yan, Zhang Lei, Huang Ye
Graduate School, Beijing University of Chinese Medicine, Beijing, China.
Emergency Department, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Front Immunol. 2025 Jun 16;16:1607932. doi: 10.3389/fimmu.2025.1607932. eCollection 2025.
Atherosclerosis is a chronic vascular inflammatory disease in which macrophages play a pivotal role in modulating its pathology. In response to the intraplaque microenvironment, both pro-inflammatory M1 and anti-inflammatory M2 phenotypes of macrophages have the polarization capability, each influencing the inflammatory state through the secretion of distinct cytokines. N6-methyladenosine (m6A) modification, the most prevalent internal chemical modification of RNA, significantly impacts various biological processes, including RNA transcription and protein expression. m6A modification acts as a critical determinant in macrophage polarization, with its molecular mechanisms intricately linked to the progression of atherosclerosis. This review aims to elucidate how different macrophage polarization phenotypes influence the progression of atherosclerosis while also exploring the significance of m6A modifications in this pathological context, thereby providing a theoretical foundation for identifying novel diagnostic and therapeutic targets for atherosclerosis.
动脉粥样硬化是一种慢性血管炎症性疾病，其中巨噬细胞在调节其病理过程中起关键作用。响应斑块内微环境，巨噬细胞的促炎M1型和抗炎M2型均具有极化能力，每种类型通过分泌不同的细胞因子影响炎症状态。N6-甲基腺苷（m6A）修饰是RNA最普遍的内部化学修饰，显著影响包括RNA转录和蛋白质表达在内的各种生物学过程。m6A修饰是巨噬细胞极化的关键决定因素，其分子机制与动脉粥样硬化的进展密切相关。本综述旨在阐明不同的巨噬细胞极化表型如何影响动脉粥样硬化的进展，同时探讨m6A修饰在这一病理背景下的意义，从而为确定动脉粥样硬化的新型诊断和治疗靶点提供理论基础。
