Rudman D, Kutner M H, Chawla R K
Pediatr Res. 1985 Oct;19(10):975-80. doi: 10.1203/00006450-198510000-00001.
In 59 male and 59 female healthy children of average stature between 7 and 10 yr old, the normal range of plasma somatomedin C was investigated. The 95% tolerance limits narrowed progressively when the child's plasma somatomedin C status was described by the mean of one, two, three, or four determinations at 6-wk intervals. The 95% tolerance limits were therefore based on the mean of four determinations. In 97 children, age 7 to 10, below the 3.0 percentile in height, 44 had an average plasma somatomedin C below the 2.5 percentile. Among these hyposomatomedinemic short children, 19 were partially or totally deficient in growth hormone, 20 had normal immunoreactive growth hormone responses to dopa, glucagon, and sleep (nongrowth hormone deficient), and five had borderline provocative tests. Both growth hormone deficient and nongrowth hormone deficient children showed significant linear growth responses to 6-month courses of human growth hormone (0.16 to 0.70 unit/kg/wk). The responses of the latter group were 50 to 90% as great as those of the former.
对59名7至10岁平均身高的健康男童和59名健康女童的血浆生长调节素C正常范围进行了研究。当每隔6周通过一次、两次、三次或四次测定的平均值来描述儿童的血浆生长调节素C状态时，95%的耐受限度逐渐变窄。因此，95%的耐受限度是基于四次测定的平均值。在97名7至10岁身高低于第3百分位数的儿童中，44名儿童的血浆生长调节素C平均值低于第2.5百分位数。在这些生长调节素C水平低下的矮身材儿童中，19名儿童生长激素部分或完全缺乏，20名儿童对多巴、胰高血糖素和睡眠的免疫反应性生长激素反应正常（非生长激素缺乏），5名儿童的激发试验结果处于临界状态。生长激素缺乏和非生长激素缺乏的儿童对6个月疗程的人生长激素（0.16至0.70单位/千克/周）均表现出显著的线性生长反应。后一组的反应是前一组的50%至90%。
