Haglund Johanna, Sundbom Fredrik, Malinovschi Andrei, Janson Christer
Department of Medical Sciences: Respiratory, Allergy and Sleep Research, Uppsala University, Uppsala, Sweden.
Department of Medical Sciences: Clinical Physiology, Uppsala University, Uppsala, Sweden.
ERJ Open Res. 2025 Jun 30;11(3). doi: 10.1183/23120541.01085-2024. eCollection 2025 May.
Asthma has been associated with a higher risk for cardiometabolic disease. One possible explanation is the activation of type 2 inflammation. We aimed to investigate whether there is an association between type 2 inflammation and cardiometabolic disease and whether the association varies between different biomarkers.
This cross-sectional study included a total of 4277 non-smoking participants with data on cardiometabolic disease and type 2 inflammation (blood eosinophil count, exhaled nitric oxide fraction ( ) and IgE sensitisation). The cut-off values of the biomarkers were ≥0.3×10 L for blood eosinophil count, ≥25 ppb for and ≥0.35 PAU·L for IgE sensitisation.
There was a higher prevalence of cardiometabolic disease among participants with any type 2 biomarker: diabetes (5.2% 3.3%; p=0.002), cardiovascular disease (CVD) (3.3% 1.8%; p=0.002) and hypertension (23.7% 20.2%; p=0.007). Diabetes had the strongest association with having all three biomarkers elevated (OR 4.03 (95% CI 1.84-8.87)), followed by elevation of both blood eosinophil count and (OR 2.38 (95% CI 1.15-4.91)) and of only blood eosinophil count (2.02 (95% CI 1.21-3.36); p=0.007). CVD was associated with the combination of elevated blood eosinophil count and IgE sensitisation (OR 4.77 (95% CI 2.11-10.79)) and with elevated (OR 2.57 (95% CI 1.31-5.06)). Hypertension was associated with elevated blood eosinophil count (OR 1.65 (95% CI 1.26-2.18)).
We found an association between type 2 inflammation and cardiometabolic disorder, but the association with the combination of markers varied between the diseases.
哮喘与发生心脏代谢疾病的较高风险相关。一种可能的解释是2型炎症的激活。我们旨在研究2型炎症与心脏代谢疾病之间是否存在关联，以及这种关联在不同生物标志物之间是否有所不同。
这项横断面研究共纳入了4277名不吸烟参与者，他们有关于心脏代谢疾病和2型炎症（血液嗜酸性粒细胞计数、呼出一氧化氮分数（ ）和IgE致敏）的数据。生物标志物的临界值为血液嗜酸性粒细胞计数≥0.3×10⁹/L， ≥25 ppb，IgE致敏≥0.35 PAU·L。
在具有任何一种2型生物标志物的参与者中，心脏代谢疾病的患病率更高：糖尿病（5.2% 对3.3%；p = 0.002）、心血管疾病（CVD）（3.3% 对1.8%；p = 0.002）和高血压（23.7% 对20.2%；p = 0.007）。糖尿病与所有三种生物标志物升高的关联最强（比值比4.03（95%置信区间1.84 - 8.87）），其次是血液嗜酸性粒细胞计数和 均升高（比值比2.38（95%置信区间1.15 - 4.91））以及仅血液嗜酸性粒细胞计数升高（2.02（95%置信区间1.21 - 3.36）；p = 0.007）。CVD与血液嗜酸性粒细胞计数升高和IgE致敏的组合相关（比值比4.77（95%置信区间2.11 - 10.79））以及与 升高相关（比值比2.57（95%置信区间1.31 - 5.06））。高血压与血液嗜酸性粒细胞计数升高相关（比值比1.65（95%置信区间1.26 - 2.18））。
我们发现2型炎症与心脏代谢紊乱之间存在关联，但与标志物组合的关联在不同疾病之间有所不同。
