Zisser Howard, Hovorka Roman, Basu Ananda, Battelino Tadej, Boughton Charlotte K, Breton Marc D, Buckingham Bruce A, Brown Sue A, Cherñavvsky Daniel R, Dassau Eyal, DeBoer Mark D, Doyle Francis J, Ekhlaspour Laya, Fabris Chiara, Forlenza Gregory P, Haidar Ahmad, Klonoff David C, Kovatchev Boris, Kowalski Aaron J, Levy Carol J, Kudva Yogish C, Maahs David M, Phillip Moshe, Renard Eric, Russell Steven J, Shah Viral N, Steil Garry M, Wadwa R Paul, Weinzimer Stuart A
Independent Researcher, Santa Barbara, CA, USA.
University of Cambridge, Cambridge, UK.
J Diabetes Sci Technol. 2025 Jul;19(4):908-923. doi: 10.1177/19322968251335685. Epub 2025 Jul 1.
The development of automated insulin delivery systems has seen tremendous improvements from individual components to interoperable system combinations of devices and new drugs besides insulin. The components have become progressively smaller, more accurate, and more user friendly. This article summarizes the history of the artificial pancreas from the earliest concepts to fully functional systems to research into further improvements in the future. The authors include many of the developers of this technology who received research support from the National Institute of Diabetes and Digestive and Kidney Diseases at various stages to develop these systems.
从单个组件到设备与除胰岛素之外的新药的可互操作系统组合，自动胰岛素输送系统取得了巨大进步。这些组件变得越来越小、越来越精确且对用户越来越友好。本文总结了人工胰腺从最早的概念到功能完备的系统，再到未来进一步改进研究的历史。作者包括这项技术的许多开发者，他们在各个阶段获得了美国国立糖尿病、消化和肾脏疾病研究所的研究支持，以开发这些系统。
