藤黄微球菌的化学适应性诱导了对O-烷基化DNA嘧啶的修复功能。
Chemical adaptation of M. luteus induces repair functions for O-alkylated DNA pyrimidines.
作者信息
Riazuddin S, Athar A, Saffhill R
出版信息
Nucleic Acids Res. 1985 Oct 11;13(19):7153-66. doi: 10.1093/nar/13.19.7153.
Abstract
A partially purified extract prepared from adapted M. luteus cells contains repair functions for oxygen methylated pyrimidine residues present in alkylated DNA. The removal of O2-MeT is mediated by a DNA glycosylase enzyme whereas disappearance of O4-MeT is effected by a methyltransferase in a manner similar to the in situ repair of O6-MeG. O4-MeT methyltransferase enzyme is unusually heat resistant. Synthesis of these repair proteins, which are distinctly different from the previously known inducible 3-MeA DNA glycosylase and O6-MeG methyltransferase activities, forms a part of the adaptive response.
摘要
从适应后的藤黄微球菌细胞中制备的部分纯化提取物，对烷基化DNA中存在的氧甲基化嘧啶残基具有修复功能。O2-MeT的去除由一种DNA糖基化酶介导，而O4-MeT的消失则由一种甲基转移酶以类似于O6-MeG原位修复的方式实现。O4-MeT甲基转移酶具有异常的耐热性。这些修复蛋白的合成与先前已知的可诱导3-MeA DNA糖基化酶和O6-MeG甲基转移酶活性明显不同，是适应性反应的一部分。
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本文引用的文献
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Adaptive response to alkylating agents involves alteration in situ of O6-methylguanine residues in DNA.对烷化剂的适应性反应涉及DNA中O6-甲基鸟嘌呤残基的原位改变。
Nature. 1979 Jul 5;280(5717):76-7. doi: 10.1038/280076a0.
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Evidence for an adaptive DNA repair pathway in CHO and human skin fibroblast cell lines.中国仓鼠卵巢细胞（CHO）和人皮肤成纤维细胞系中适应性DNA修复途径的证据。
Nature. 1980 Oct 30;287(5785):861-3. doi: 10.1038/287861a0.
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Chemical mutagenesis.化学诱变
Annu Rev Biochem. 1982;51:655-93. doi: 10.1146/annurev.bi.51.070182.003255.
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Adaptation to alkylation resistance involves the induction of a DNA glycosylase.对烷化抗性的适应涉及一种DNA糖基化酶的诱导。
Nature. 1982 Apr 22;296(5859):773-5. doi: 10.1038/296773a0.
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Induction of a DNA glycosylase for N-methylated purines is part of the adaptive response to alkylating agents.诱导一种针对N-甲基化嘌呤的DNA糖基化酶是对烷化剂适应性反应的一部分。
Nature. 1982 Apr 22;296(5859):770-3. doi: 10.1038/296770a0.
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Isolation of mutants of Escherichia coli with increased resistance to alkylating agents: mutants deficient in thiols and mutants constitutive for the adaptive response.具有增强的对烷化剂抗性的大肠杆菌突变体的分离：硫醇缺陷型突变体和适应性反应组成型突变体。
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9
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