Bakri A, Beijersbergen van Henegouwen G, Chanal J L
Photodermatol. 1985 Aug;2(4):205-12.
To verify whether or not N4-oxide function is involved in the phototoxicity of chlordiazepoxide (CDZ, Librium), photopharmacology of reduced chlordiazepoxide (RCDZ) lacking the N4-oxide group was carried out and compared to that of CDZ. From the distribution of the 2 compounds in the skin and their UV-spectra in the wavelength region of the UV lamp, doses were calculated to allow the comparison of the photopharmacological effects. Contrary to what has been described for CDZ, no difference was found for RCDZ between irradiated and non-irradiated rats. The discussion leads to the conclusion that the N4-oxide group is responsible for systemic effects reported for phototoxic CDZ.
为了验证N4-氧化物功能是否参与了氯氮卓（CDZ，利眠宁）的光毒性，对缺乏N4-氧化物基团的还原氯氮卓（RCDZ）进行了光药理学研究，并与CDZ进行了比较。根据这两种化合物在皮肤中的分布及其在紫外线灯波长区域的紫外光谱，计算出剂量，以便比较光药理效应。与CDZ的描述相反，在照射和未照射的大鼠之间未发现RCDZ有差异。讨论得出结论，N4-氧化物基团是光毒性CDZ所报告的全身效应的原因。
