Obame-Nkoghe Judicaël, Kondji Faël Moudoumi, Diouf El Hadji, Thiaw Omar, Niangui Brad Ghaven, Ondo-Oyono Arnauld, Okomo-Nguema Yasmine, Longo-Pendy Neil Michel, Mounioko Franck, Makanga Boris, Kamgang Basile, Paupy Christophe, Kengne Pierre, Otomo Patricks Voua, Niang El Hadji Amadou
Département de Biologie de l'Université des Sciences et Techniques de Masuku (USTM), BP 901, Franceville, Gabon - Unité de Recherche en Ecologie de la Santé du Centre Interdisciplinaire de Recherches Médicales de Franceville (CIRMF), BP 769, Franceville, Gabon - Department of Zoology and Entomology, Faculty of Natural and Agricultural Sciences, University of the Free State, Phuthaditjhaba 9866, Republic of South Africa.
Département de Biologie de l'Université des Sciences et Techniques de Masuku (USTM), BP 901, Franceville, Gabon.
Parasite. 2025;32:40. doi: 10.1051/parasite/2025036. Epub 2025 Jul 1.
The spread of resistance to insecticides, such as pyrethroids, in Aedes vectors increases the risk of spread of arboviral diseases. In Gabon, the insecticide resistance profiles of Ae. aegypti and Ae. albopictus species remain poorly known. During a study to monitor the dynamics of Aedes populations in Franceville, in south-east Gabon, the resistance profiles of these two species to pyrethroids, organophosphates and carbamates were assessed. Susceptibility tests on adults and synergist tests with piperonyl butoxide (PBO) were carried out as per the World Health Organization protocol. The results showed that Ae. aegypti and Ae. albopictus were susceptible to permethrin, pirimiphos-methyl and bendiocarb. However, both species were resistant to deltamethrin (mortality: 67% for Ae. aegypti; 33% for Ae. albopictus). Exposure to a 5-fold dose of deltamethrin increased mortality to 100% and 91% for Ae. aegypti and Ae. albopictus, respectively. Resistance to alpha-cypermethrin was also recorded (mortality: 82% for Ae. aegypti; 64.6% for Ae. albopictus). Pre-exposure to PBO resulted in the restoration of susceptibility to deltamethrin and alpha-cypermethrin for Ae. aegypti, and a significant increase in mortality for Ae. albopictus. These data provide the first evidence of pyrethroid resistance in Aedes in Gabon and could help to establish more effective control measures against arbovirus vectors.
诸如拟除虫菊酯等杀虫剂在伊蚊媒介中的抗性传播增加了虫媒病毒疾病传播的风险。在加蓬，埃及伊蚊和白纹伊蚊的杀虫剂抗性情况仍鲜为人知。在一项监测加蓬东南部弗朗斯维尔伊蚊种群动态的研究中，评估了这两个物种对拟除虫菊酯、有机磷和氨基甲酸酯的抗性情况。按照世界卫生组织的方案对成虫进行了敏感性测试，并使用胡椒基丁醚（PBO）进行了增效剂测试。结果表明，埃及伊蚊和白纹伊蚊对氯菊酯、甲基嘧啶磷和恶虫威敏感。然而，这两个物种均对溴氰菊酯具有抗性（死亡率：埃及伊蚊为67%；白纹伊蚊为33%）。接触5倍剂量的溴氰菊酯可使埃及伊蚊和白纹伊蚊的死亡率分别增至100%和91%。对α-氯氰菊酯的抗性也有记录（死亡率：埃及伊蚊为82%；白纹伊蚊为64.6%）。预先接触PBO可使埃及伊蚊恢复对溴氰菊酯和α-氯氰菊酯的敏感性，并使白纹伊蚊的死亡率显著增加。这些数据首次证明了加蓬伊蚊对拟除虫菊酯具有抗性，并有助于制定针对虫媒病毒媒介更有效的控制措施。
