Zhang Shuo, Chen Huiyue, Li Long, Li Zhipeng, Wang Dan
Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China.
Department of Neurosurgery, The First Hospital of China Medical University, Shenyang, China.
Ecotoxicol Environ Saf. 2025 Sep 1;302:118536. doi: 10.1016/j.ecoenv.2025.118536. Epub 2025 Jun 30.
Exposure to microplastics poses potential risks to human health, particularly during pregnancy and early life; however, research in this field remains scarce. Therefore, we aimed to investigate the association between prenatal microplastic exposure and telomere length (TL), a recognized marker of biological aging. Placental microplastic exposure and its potential effects on umbilical cord blood TL and placental tissues were investigated in a cohort of 1121 pregnant women from Shenyang, China. Microplastic concentrations in placental samples were quantified using LD-IR chemical imaging, while TL in umbilical cord blood and placental tissues was measured using qRT-PCR. Adjusted multivariable regression models, stratified analysis, and mixture analyses, including Bayesian Kernel Machine Regression (BKMR) and quantile g-computation, were employed to assess associations and interactions. Placental microplastics (particularly polyvinyl chloride (PVC), polypropylene (PP), and polybutylene succinate (PBS)), were prevalent, with median total concentrations of 15 n/10 g of placental tissue. In cord blood, higher PVC and PBS levels were significantly associated with reduced TL (adjusted β = -0.13 and -0.14, respectively; p ≤ 0.01). PP exposure showed no significant association with cord blood TL. For placental TL, all three microplastics demonstrated significant negative associations, with PP showing the strongest effect (β = -0.13, p < 0.001). Stratified analysis revealed no sex-based differences in associations. Quantile g-computation indicated significant cumulative effects of microplastics on TL, with PBS contributing the most to TL reduction. BKMR analysis highlighted non-linear exposure-response relationships, with lower quantiles showing positive associations and higher quantiles indicating detrimental effects on TL, potentially due to oxidative stress or inflammation. These findings underscore the pervasive presence of microplastics in placental tissues and their potential role in disrupting telomere maintenance, raising concerns about their long-term health implications for newborns.
