1%联苯苄唑凝胶治疗体癣或股癣：一项开放性多中心研究。

Treatment of tinea corporis or tinea cruris with bifonazole 1% gel: an open, multicentre study.

作者信息

Belli L, Galimberti R, Negroni R, Rohwedder R, Castro J M

出版信息

Pharmatherapeutica. 1985;4(2):106-8.

Abstract

An open, multicentre study was carried out in 103 patients with confirmed dermatophyte infections (tinea cruris or tinea corporis). The fungi isolated were Tr. rubrum (45), Tr. mentagrophytes (11), Ep. floccosum (26) and M. canis (21). All patients were treated with a single daily application of bifonazole (1% gel) and the duration of treatment was 3 weeks. Weekly clinical controls were performed during the therapeutic period and at least two clinical and mycological examinations were given after the end of treatment. Treatment was evaluated according to the clinical and mycological findings at the 14th post-therapeutic day. The results obtained were classified as very good in 80 patients, good in 11, moderate in 11 and failure in 1 patient. Local tolerance was very good and no side-effects were observed in any patients.

摘要

对103例确诊为皮肤癣菌感染（股癣或体癣）的患者进行了一项开放性多中心研究。分离出的真菌有红色毛癣菌（45例）、须癣毛癣菌（11例）、絮状表皮癣菌（26例）和犬小孢子菌（21例）。所有患者每日单次外用联苯苄唑（1%凝胶），疗程为3周。治疗期间每周进行临床检查，治疗结束后至少进行两次临床和真菌学检查。根据治疗后第14天的临床和真菌学结果评估疗效。结果显示，80例患者疗效极佳，11例良好，11例中等，1例失败。局部耐受性非常好，所有患者均未观察到副作用。