Ji Ming-Fang, He Yong-Qiao, Tang Min-Zhong, Xue Wen-Qiong, Yu Xia, Diao Hua, Yang Da-Wei, Mai Zhi-Ming, Cheong Io Hong, Zhao Zhi-Yang, Wu Biao-Hua, Li Fu-Gui, Zhan Ji-Yun, Huang Chang-Ling, Ma Hao-Lin, Li Jun, Li Yan-Cheng, Wang Tong-Min, Liao Ying, Chen Xue-Yin, Liang Zhi-Heng, Lian Shi-Feng, Du Yun, Liang Xue-Jun, Kozlakidis Zisis, Ma Jun, Jia Wei-Hua
Cancer Research Institute of Zhongshan City, Zhongshan City People's Hospital, Zhongshan, Guangdong, P. R. China.
State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, P. R. China.
Nat Commun. 2025 Jul 1;16(1):5940. doi: 10.1038/s41467-025-60999-5.
Epstein-Barr virus (EBV) has been implicated in several human cancers, but its broader cancer risk remains unclear. We investigated the association between EBV VCA-IgA antibody levels and cancer risk in two large prospective cohorts from Southern China, comprising 73,939 adults. During around 8-10 years follow-up, 964 and 1026 incident cancer cases were identified in the Zhongshan and Wuzhou cohorts. VCA-IgA seropositivity was associated with higher age-standardized incidence rates for total cancer significantly. In pooled analyses, VCA-IgA seropositive individuals had higher risks of total cancer (HR 4.88, 95% CI: 2.84-8.37), lung cancer (1.76, 1.23-2.54), liver cancer (1.70, 1.10-2.63), nasopharyngeal carcinoma (26.05, 11.77-57.65), and lymphoma (3.20, 1.46-6.99) compared to seronegative individuals. The associations showed an increased dose-response pattern, and keep persistent even up to ten years prior to diagnosis. The population-attributable risk percentage for total cancer due to VCA-IgA seropositivity is estimated at 7.8%. These findings provide prospective evidence that EBV seropositivity is associated with increased risks of multiple cancers. This association results in a heightened attributed cancer burden in Southern China.
爱泼斯坦-巴尔病毒（EBV）与多种人类癌症有关，但其更广泛的癌症风险仍不明确。我们在中国南方的两个大型前瞻性队列中调查了EBV VCA-IgA抗体水平与癌症风险之间的关联，这两个队列共有73939名成年人。在大约8至10年的随访期间，中山队列和梧州队列分别确诊了964例和1026例新发癌症病例。VCA-IgA血清阳性与总体癌症的年龄标准化发病率显著升高相关。在汇总分析中，与血清阴性个体相比，VCA-IgA血清阳性个体患总体癌症（风险比4.88，95%置信区间：2.84 - 8.37）、肺癌（1.76，1.23 - 2.54）、肝癌（1.70，1.10 - 2.63）、鼻咽癌（26.05，11.77 - 57.65）和淋巴瘤（3.20，1.46 - 6.99）的风险更高。这些关联呈现出剂量反应增加的模式，并且在诊断前长达十年都持续存在。因VCA-IgA血清阳性导致的总体癌症人群归因风险百分比估计为7.8%。这些发现提供了前瞻性证据，表明EBV血清阳性与多种癌症风险增加有关。这种关联导致中国南方归因的癌症负担加重。
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