Gu Jiawei, Bao Yujia, Li Yongxuan, Chen Xuhua, Yuan Shenghao, Zhang Yuzheng, Pan Haozhi, Deng Xiaobei, Han Lefei, Ran Jinjun
School of Public Health, Shanghai Jiao Tong University School of Medicine, 413 East No. 1 Bldg, 227 South Chongqing Rd, Shanghai, 200025, China.
National Center for Mental Health, Beijing, China.
Sci Rep. 2025 Jul 2;15(1):22994. doi: 10.1038/s41598-025-06994-8.
The global rise in mental disorders presents a significant public health challenge, highlighting the need for a deeper understanding of their underlying risk factors. Existing studies on obesity and brain health primarily rely on metrics such as body mass index and waist-to-hip ratio, which inadequately capture central obesity, a fat distribution strongly associated with increased health risks. This underscores the need for more precise metrics, with the body roundness index (BRI) emerging as a promising option. 321,596 UK Biobank participants were analyzed in this study. Cox regression models assessed associations between BRI and incident mental disorders, while logistic and multiple linear regression models explored relationships with psychiatric symptoms and white matter integrity, respectively. Results indicated that higher BRI was significantly associated with increased risks of incident overall mental disorders (HR [95% CI] = 1.12 [1.09, 1.15]), as well as specific high-prevalence disorders including substance use disorder (1.05 [1.01, 1.11]), depressive disorder (1.34 [1.24, 1.45]), and anxiety disorder (1.09 [1.03, 1.15]). An overall positive association was also observed between elevated BRI and adverse psychiatric symptoms and reduced white matter integrity. These findings highlighted BRI as a potential indicator of mental health. BRI's association with clinical and subclinical psychiatric outcomes emphasized its relevance in understanding the interplay between central adiposity and brain health.
全球精神障碍的增多带来了重大的公共卫生挑战，凸显了深入了解其潜在风险因素的必要性。现有的关于肥胖与大脑健康的研究主要依赖于体重指数和腰臀比等指标，而这些指标无法充分反映中心性肥胖，即一种与健康风险增加密切相关的脂肪分布类型。这就强调了需要更精确的指标，而身体圆润度指数（BRI）已成为一个有前景的选择。本研究分析了英国生物银行的321,596名参与者。Cox回归模型评估了BRI与新发精神障碍之间的关联，而逻辑回归模型和多元线性回归模型分别探讨了其与精神症状和白质完整性的关系。结果表明，较高的BRI与新发总体精神障碍风险增加显著相关（风险比[95%置信区间]=1.12[1.09,1.15]），以及与特定的高发性疾病相关，包括物质使用障碍（1.05[1.01,1.11]）、抑郁症（1.34[1.24,1.45]）和焦虑症（1.09[1.03,1.15]）。BRI升高与不良精神症状及白质完整性降低之间也观察到总体正相关。这些发现突出了BRI作为心理健康潜在指标的作用。BRI与临床和亚临床精神科结局的关联强调了其在理解中心性肥胖与大脑健康相互作用方面的相关性。
