Department of Urology, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei, China.
School of Public Health, Ningxia Medical University, Yinchuan, Ningxia, China.
Front Endocrinol (Lausanne). 2024 Sep 26;15:1482003. doi: 10.3389/fendo.2024.1482003. eCollection 2024.
Depression is a common mental illness with a high prevalence in overweight or obese individuals. Recent studies suggest that the Metabolic Score for Visceral Fat (METS-VF) is a novel metric for assessing visceral fat levels, potentially linking metabolic disturbances to depression. This study explores the association between METS-VF and depression severity in overweight or obese U.S. adults.
Data were obtained from the National Health and Nutrition Examination Survey (NHANES) 2007-2018 dataset, including 9,415 overweight or obese participants. Depression severity was measured using the Patient Health Questionnaire-9 (PHQ-9). To assess the association between METS-VF and depression, the study methodology included multivariate logistic regression, subgroup analyses, generalized additive model (GAM), and smoothed curve fitting. This study also calculated BMI for the Non-Hispanic Asian population from 2011-2018 and incorporated this data as part of a sensitivity analysis.
Elevated levels of METS-VF in overweight or obese participants were significantly associated with increased PHQ-9 scores and an increased likelihood of depression. Notably, this association remained significant after adjustment for multiple covariates. Smoothed curve-fitting plots showed no nonlinear association between METS-VF and PHQ-9 scores. Subgroup analyses confirmed the robustness of these results across populations, particularly among people under the age of fifty. The sensitivity analyses confirmed the robustness of the results in this study.
METS-VF levels were positively associated with depression severity and the likelihood of depression in overweight or obese individuals, with the association being particularly pronounced in people under 50 years of age.
抑郁症是一种常见的精神疾病，在超重或肥胖人群中的发病率较高。最近的研究表明，内脏脂肪代谢评分（METS-VF）是一种评估内脏脂肪水平的新指标，可能将代谢紊乱与抑郁症联系起来。本研究探讨了 METS-VF 与超重或肥胖的美国成年人中抑郁严重程度之间的关系。
数据来自国家健康和营养检查调查（NHANES）2007-2018 年数据集，包括 9415 名超重或肥胖参与者。使用患者健康问卷-9（PHQ-9）评估抑郁严重程度。为了评估 METS-VF 与抑郁之间的关联，研究方法包括多变量逻辑回归、亚组分析、广义加性模型（GAM）和平滑曲线拟合。本研究还计算了 2011-2018 年非西班牙裔亚裔人群的 BMI，并将这些数据纳入敏感性分析的一部分。
超重或肥胖参与者中 METS-VF 水平升高与 PHQ-9 评分升高和抑郁发生的可能性增加显著相关。值得注意的是，在调整了多个协变量后，这种关联仍然显著。平滑曲线拟合图显示，METS-VF 与 PHQ-9 评分之间没有非线性关系。亚组分析证实了这些结果在不同人群中的稳健性，特别是在 50 岁以下的人群中。敏感性分析证实了本研究结果的稳健性。
METS-VF 水平与超重或肥胖个体的抑郁严重程度和抑郁发生的可能性呈正相关，这种关联在 50 岁以下的人群中尤为明显。
