Effect of polyamines on perfused rat heart contractility.
作者信息
Bazzani C, Genedani S, Bertolini A
出版信息
Pharmacol Res Commun. 1985 Sep;17(9):873-81. doi: 10.1016/0031-6989(85)90046-3.
PMID:4059321
Abstract
The influence of polyamines (putrescine, spermidine and spermine) on heart contractility was studied using perfused rat ventricle strips (2 X 10 mm), electrically driven at 1 Hz. Putrescine (100 microM) caused a negative inotropic effect gradually increasing in intensity, whereas spermidine and spermine (10 and 100 microM) caused a sharp, positive inotropic effect, followed by a rapid and more marked fall. The possibility that these effects of polyamines on heart contractility may be due to their role in Ca++ fluxes and mobilization, and in membrane functions, is discussed.
摘要
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