Omilian Angela R, Mendicino Lucas, George Anthony, Darabnoushtehrani Tina, Ondracek Rochelle Payne, Bshara Wiam, Hong Chi-Chen, Qin Bo, Bandera Elisa V, Khoury Thaer, Cannioto Rikki, Yao Song, Ambrosone Christine B
Department of Cancer Prevention and Control, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.
Department of Pathology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.
NPJ Breast Cancer. 2025 Jul 1;11(1):64. doi: 10.1038/s41523-025-00780-5.
We compared T cell subpopulations in primary invasive breast tumors from Black and White women and investigated breast cancer subtype-specific associations of T cell abundance with survival in Black women. Multispectral immune staining was used to quantify helper, cytotoxic, and regulatory T cells in the tumor and stromal compartments of breast tissues. In fully adjusted models, breast tumors from Black women were significantly more likely than those from White women to have a higher abundance of cytotoxic T cells (IRR, 2.41; 95% CI, 1.43-4.05) and helper T cells (IRR, 1.80; 95% CI, 1.06-3.06), and these differences were more pronounced in the tumor than the stromal compartment. Among Black women, higher levels of T cells were associated with improved survival in women with triple-negative breast cancer, whereas a trend of poorer survival was observed in women with HER2-positive tumors. This study contributes to an accumulating body of evidence that the tumor-immune landscape differs between Black and White women.
我们比较了黑人和白人女性原发性浸润性乳腺癌中的T细胞亚群，并研究了黑人女性中T细胞丰度与生存的乳腺癌亚型特异性关联。采用多光谱免疫染色法对乳腺组织肿瘤和基质区室中的辅助性T细胞、细胞毒性T细胞和调节性T细胞进行定量。在完全调整模型中，黑人女性的乳腺肿瘤比白人女性的肿瘤更有可能具有更高丰度的细胞毒性T细胞（发病率比值比[IRR]，2.41；95%置信区间[CI]，1.43 - 4.05）和辅助性T细胞（IRR，1.80；95% CI，1.06 - 3.06），且这些差异在肿瘤区室比基质区室更明显。在黑人女性中，T细胞水平较高与三阴性乳腺癌女性的生存改善相关，而在HER2阳性肿瘤女性中观察到生存较差的趋势。这项研究为越来越多的证据提供了补充，即黑人和白人女性的肿瘤免疫格局不同。
