Zhou Wang, Zhang Xi-Ran, Qin Xia-Chuan, Xie Yu-Chen, Zhang Di, Wang Zi-Cheng, Zhang Chao-Xue
Department of Ultrasound, The First Affiliated Hospital of Anhui Medical University, No.218 Jixi Road, Shushan District, Hefei, 230022, Anhui, China.
Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, No.81 Meishan Road, Hefei, 230032, Anhui, China.
Sci Rep. 2025 Jul 1;15(1):20843. doi: 10.1038/s41598-025-04916-2.
Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a debilitating condition characterized by pelvic pain and discomfort, necessitating the exploration of effective therapeutic strategies. This study aimed to elucidate the therapeutic potential of naringin (NAR) in addressing CP/CPPS by examining its role in modulating oxidative stress (OS) and the NLRP3 inflammasome via the PPARγ/NF-κB signaling pathway. Using both animal and cellular models of CP/CPPS, naringin was administered to mice with experimental autoimmune prostatitis (EAP), and the anti-inflammatory effect of naringin was assessed. Furthermore, cellular assays were performed to investigate the mechanistic pathway underlying the effects of naringin, with a focus on its role in mitigating oxidative stress and suppressing NLRP3 inflammasome activation. The results indicated that naringin significantly reduced inflammation in both models by effectively inhibiting NLRP3 inflammasome activation and restoring cellular homeostasis via oxidative stress modulation linked to the activation of the PPARγ/NF-κB axis. In conclusion, naringin showed promising therapeutic effects in mitigating inflammation associated with CP/CPPS, highlighting its potential as a novel treatment option. Further investigations into the clinical applicability of naringin are needed to fully understand its therapeutic potential in patients suffering from CP/CPPS.
慢性前列腺炎/慢性盆腔疼痛综合征（CP/CPPS）是一种使人衰弱的病症，其特征为盆腔疼痛和不适，因此需要探索有效的治疗策略。本研究旨在通过研究柚皮苷（NAR）通过PPARγ/NF-κB信号通路调节氧化应激（OS）和NLRP3炎性小体的作用，阐明其在治疗CP/CPPS中的潜力。使用CP/CPPS的动物和细胞模型，将柚皮苷给予实验性自身免疫性前列腺炎（EAP）小鼠，并评估柚皮苷的抗炎作用。此外，进行细胞试验以研究柚皮苷作用的机制途径，重点是其在减轻氧化应激和抑制NLRP3炎性小体激活中的作用。结果表明，柚皮苷通过有效抑制NLRP3炎性小体激活并通过与PPARγ/NF-κB轴激活相关的氧化应激调节恢复细胞稳态，从而在两种模型中均显著减轻炎症。总之，柚皮苷在减轻与CP/CPPS相关的炎症方面显示出有前景的治疗效果，突出了其作为一种新型治疗选择的潜力。需要进一步研究柚皮苷的临床适用性，以充分了解其在CP/CPPS患者中的治疗潜力。
