Dhar Swati, Adiga Prashanth, Mundkur Anjali, Poojari Vidyashree Ganesh, Kumar Pratap
Department of Reproductive Medicine and Surgery, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, 576104, Manipal, Karnataka, India.
Sci Rep. 2025 Jul 1;15(1):21998. doi: 10.1038/s41598-025-05851-y.
Cleavage-stage embryo transfers are often the best option for patients with limited oocytes or low fertilization rates due to medical or financial constraints. This study analyzed 424 women undergoing β-hCG testing 14 days after embryo transfer at a tertiary care center in India. Pregnancy outcomes were classified as no live births (biochemical pregnancies, ectopic pregnancies, miscarriages) or live births (single/multiple births). Higher β-hCG levels were associated with greater chances of live birth but also an increased risk of complications like preterm birth and preeclampsia, particularly in multiple pregnancies. A β-hCG threshold of 468 mIU/mL was identified as the optimal predictor of live birth, with 75% sensitivity and 72% specificity. Receiver operating characteristic (ROC) curve analysis confirmed its strong predictive value. By reducing the need for frequent monitoring, this single-test approach helps ease the emotional, financial, and logistical burdens patients face during IVF treatment. The study highlights β-hCG as a simple, cost-effective tool for providing early reassurance, guiding counseling, and personalizing follow-up, particularly in low-resource settings where access to fertility care remains challenging.
由于医学或经济限制，卵裂期胚胎移植通常是卵母细胞数量有限或受精率低的患者的最佳选择。本研究分析了印度一家三级医疗中心424名在胚胎移植14天后接受β - hCG检测的女性。妊娠结局分为无活产（生化妊娠、异位妊娠、流产）或活产（单胎/多胎分娩）。较高的β - hCG水平与活产几率增加相关，但也会增加早产和先兆子痫等并发症的风险，尤其是在多胎妊娠中。β - hCG阈值468 mIU/mL被确定为活产的最佳预测指标，灵敏度为75%，特异度为72%。受试者工作特征（ROC）曲线分析证实了其强大的预测价值。通过减少频繁监测的需求，这种单一检测方法有助于减轻患者在体外受精治疗期间面临的情感、经济和后勤负担。该研究强调β - hCG是一种简单、经济有效的工具，可提供早期安慰、指导咨询并实现随访个性化，特别是在获得生育护理仍具有挑战性的资源匮乏地区。
