相对脂肪量与女性不孕症的关联：一项基于2017 - 2020年美国国家健康与营养检查调查（NHANES）的横断面研究。

Association of relative fat mass with female infertility: a cross-sectional study based on NHANES 2017-2020.

作者信息

Tang Qian, Zhang Qiang, Xia Rui, Li Xitong, Du Jing, Cheng Yaoping, Wang Ling

机构信息

Reproductive Centre, The 940th Hospital of the Joint Logistic Support Force of PLA, Lanzhou, 730050, China.

Gansu University of Chinese Medicine, Lanzhou, China.

出版信息

Sci Rep. 2025 Jul 2;15(1):22713. doi: 10.1038/s41598-025-08595-x.

DOI:10.1038/s41598-025-08595-x

PMID:40595186

Abstract

Relative Fat Mass (RFM) is an emerging body fat measurement index that more accurately reflects the distribution of visceral fat. This study aimed to investigate the association between RFM and female infertility. We utilized data from the National Health and Nutrition Examination Survey (NHANES) spanning from 2017 to 2020, enrolling 1487 female participants aged 20-44. The relationship between RFM and infertility was analyzed using multivariate Logistic regression, and the dose-response relationship was assessed with Restricted Cubic Splines (RCS). The study found a significant association between RFM and infertility. After adjusting for confounders such as age, ethnicity, and BMI, each unit increase in RFM was associated with a 6% increase in the risk of infertility (OR = 1.06, 95%CI = 1.01-1.12, P = 0.019), with stable results across different subgroups. RFM is significantly associated with female infertility and may serve as a useful tool in infertility screening. Future studies should further validate its potential for clinical application.

摘要

相对脂肪量（RFM）是一种新兴的体脂测量指标，能更准确地反映内脏脂肪分布。本研究旨在探讨RFM与女性不孕症之间的关联。我们利用了2017年至2020年美国国家健康与营养检查调查（NHANES）的数据，纳入了1487名年龄在20 - 44岁之间的女性参与者。采用多因素Logistic回归分析RFM与不孕症之间的关系，并使用受限立方样条（RCS）评估剂量反应关系。研究发现RFM与不孕症之间存在显著关联。在调整年龄、种族和BMI等混杂因素后，RFM每增加一个单位，不孕症风险增加6%（OR = 1.06，95%CI = 1.01 - 1.12，P = 0.019），不同亚组结果稳定。RFM与女性不孕症显著相关，可能成为不孕症筛查的有用工具。未来研究应进一步验证其临床应用潜力。