感受态肺炎球菌细胞中细胞分裂的短暂抑制是由隔膜肽聚糖复合物的减速引起的。
Transient inhibition of cell division in competent pneumococcal cells results from deceleration of the septal peptidoglycan complex.
作者信息
Juillot Dimitri, Billaudeau Cyrille, Mortier-Barrière Isabelle, Barbotin Aurélien, Lablaine Armand, Polard Patrice, Campo Nathalie, Carballido-López Rut
机构信息
Université Paris-Saclay, INRAE, AgroParisTech, Micalis Institute, 78350, Jouy-en-Josas, France.
Laboratoire de Microbiologie et Génétique Moléculaires, UMR5100, Centre de Biologie Intégrative, Centre Nationale de la Recherche Scientifique, 31062, Toulouse, France.
出版信息
Nat Commun. 2025 Jul 1;16(1):5666. doi: 10.1038/s41467-025-60600-z.
Membrane protein ComM transiently inhibits cell division during the development of the competence state in the pathogenic bacterium Streptococcus pneumoniae, but the underlying molecular mechanisms remain unclear. Here we show that, in competent cells, ComM moves together with, and reduces the speed of, septal peptidoglycan synthetic complex FtsW:PBP2x. ComM directly interacts with the putative FtsW:PBP2x activator DivIB, and overproduction of DivIB counteracts FtsW:PBP2x deceleration along the cell division delay in competent cells. Our results support a model in which ComM reduces septal peptidoglycan synthesis by interfering with DivIB activity during competence in S. pneumoniae.
膜蛋白ComM在致病性细菌肺炎链球菌感受态状态发育过程中短暂抑制细胞分裂，但其潜在分子机制仍不清楚。在这里，我们表明，在感受态细胞中，ComM与隔膜肽聚糖合成复合物FtsW:PBP2x一起移动，并降低其速度。ComM直接与假定的FtsW:PBP2x激活剂DivIB相互作用，DivIB的过量表达抵消了感受态细胞中FtsW:PBP2x沿细胞分裂延迟的减速。我们的结果支持了一个模型，即ComM通过在肺炎链球菌感受态期间干扰DivIB活性来减少隔膜肽聚糖的合成。
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