Grossman L W, Fernandez-Ulloa M, Lukes S J, Mantil J
Radiology. 1985 Dec;157(3):789-93. doi: 10.1148/radiology.157.3.4059564.
A conjugate-view technique is derived for calculation of absolute gallium-67 (Ga-67) uptake from scintillation-camera images. The technique combines counts of posterior and anterior images of the lung with an attenuation correction obtained from cobalt-57 (Co-57) transmission imaging. The formulation is such that the effects of Compton scatter build-up are accounted for. Studies utilizing a canine model indicated that, normally, more activity is located in the chest wall than in the lungs. The quantitative technique must therefore accurately account for a variety of Ga-67 distributions, including that in the chest wall. Calculations were performed using a three-component model comparing results obtained with the conjugate-view approach to the actual uptake. These calculations suggest that an assumption of uniform activity distribution allows an accuracy of approximately +/- 10% over a broad range of body-part thicknesses and uptake by the lungs. It was concluded that the conjugate-view technique is necessarily approximate but can provide clinically useful results.
推导了一种共轭视图技术，用于从闪烁相机图像计算绝对镓-67（Ga-67）摄取量。该技术将肺部后前位图像的计数与从钴-57（Co-57）透射成像获得的衰减校正相结合。该公式考虑了康普顿散射积累的影响。利用犬模型进行的研究表明，正常情况下，胸壁中的活性比肺中的活性更多。因此，定量技术必须准确考虑各种Ga-67分布，包括胸壁中的分布。使用三组分模型进行计算，将共轭视图方法获得的结果与实际摄取量进行比较。这些计算表明，在广泛的身体部位厚度和肺部摄取范围内，假设活性分布均匀可实现约+/- 10%的准确度。得出的结论是，共轭视图技术必然是近似的，但可以提供临床有用的结果。
