Feldman M, Moore L, Walsh J H
Regul Pept. 1985 Jul;11(3):245-50. doi: 10.1016/0167-0115(85)90056-4.
We evaluated whether nalmefene, an orally administered opiate-receptor antagonist, would inhibit gastric acid secretion in response to a meal in healthy humans. On separate days either 50 mg nalmefene or a placebo tablet was administered by mouth 90 min before a blenderized steak meal was infused into the stomach through a nasogastric tube. Compared to placebo, nalmefene inhibited meal-stimulated acid secretion in each of 6 subjects studied (P less than 0.05). During the second and third hours after the meal, nalmefene inhibited mean acid secretion by 16%. Nalmefene also resulted in significantly higher meal-stimulated serum gastrin concentrations than placebo (P less than 0.05) even though intragastric pH was kept constant at 5.0 in both experiments. These studies indicate that an orally administered opiate-receptor antagonist can inhibit gastric acid secretion in response to a meal in humans, yet increase meal-stimulated serum gastrin concentrations.
我们评估了口服阿片受体拮抗剂纳美芬是否会抑制健康人进食后胃酸分泌。在不同的日子里，在通过鼻胃管将搅拌好的牛排餐注入胃内前90分钟，分别口服50毫克纳美芬或安慰剂片。与安慰剂相比，纳美芬在6名研究对象中均抑制了进食刺激的胃酸分泌（P小于0.05）。进食后第二和第三小时，纳美芬使平均胃酸分泌抑制了16%。尽管在两个实验中胃内pH值均保持在5.0不变，但纳美芬还导致进食刺激的血清胃泌素浓度显著高于安慰剂（P小于0.05）。这些研究表明，口服阿片受体拮抗剂可抑制人类进食后的胃酸分泌，但会增加进食刺激的血清胃泌素浓度。
