抗缪勒管激素在晚育年龄的预测价值：一项回顾性队列研究。

Predictive value of AMH in late reproductive age: a retrospective cohort study.

作者信息

Kozar Nejc, Gavrić Lovrec Vida, Kovačič Borut, Reljič Milan

机构信息

Department of Reproductive Medicine and Gynaecological Endocrinology, University Medical Centre Maribor, Ljubljanska ulica 5, 2000, Maribor, Slovenia.

Faculty of Medicine, University of Maribor, Taborska ulica 8, 2000, Maribor, Slovenia.

出版信息

Sci Rep. 2025 Jul 1;15(1):21073. doi: 10.1038/s41598-025-07411-w.

DOI:10.1038/s41598-025-07411-w

PMID:40596221

Abstract

This study evaluates the predictive value of Anti-Müllerian Hormone (AMH) levels on outcomes in medically assisted reproduction (MAR), with a focus on women of late reproductive age. AMH, produced by granulosa cells in ovarian follicles, serves as an important indicator of ovarian reserve. A retrospective cohort analysis was conducted, encompassing 4891 MAR cycles, to assess the age-specific predictive value of AMH for clinical pregnancy. The results indicate that AMH is significantly correlated with clinical pregnancy outcomes (p < 0.01) and demonstrates potential predictive value in women over 35 years of age, with its predictive capacity increasing notably with age (AUC = 0.62-0.69). However, in younger women, the correlation between AMH levels and MAR outcomes is weaker (AUC = 0.48-0.53). These findings highlight the importance of integrating AMH measurements with age when assessing fertility potential and tailoring MAR treatments, particularly for women approaching the end of their reproductive lifespan.

摘要

本研究评估抗苗勒管激素（AMH）水平对医学辅助生殖（MAR）结局的预测价值，重点关注晚育年龄女性。AMH由卵巢卵泡中的颗粒细胞产生，是卵巢储备的重要指标。进行了一项回顾性队列分析，涵盖4891个MAR周期，以评估AMH对临床妊娠的年龄特异性预测价值。结果表明，AMH与临床妊娠结局显著相关（p < 0.01），在35岁以上女性中显示出潜在的预测价值，其预测能力随年龄显著增加（AUC = 0.62 - 0.69）。然而，在年轻女性中，AMH水平与MAR结局之间的相关性较弱（AUC = 0.48 - 0.53）。这些发现突出了在评估生育潜力和定制MAR治疗时，将AMH测量与年龄相结合的重要性，特别是对于接近生殖寿命末期的女性。