Heidary Zohreh, Masoumi Masoumeh, Dashtkoohi Mohadese, Sharifinejad Niusha, Dehghan Tarzjani Masoumeh, Ghaemi Marjan, Hossein Rashidi Batool
Vali-E-Asr Reproductive Health Research Center, Family Health Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
Non-Communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran.
J Reprod Infertil. 2024 Jan-Mar;25(1):38-45. doi: 10.18502/jri.v25i1.15197.
The recognized role of Anti-Müllerian hormone (AMH) as a marker for women's biological age and ovarian reserve prompts debate on its efficacy in predicting oocyte quality during IVF/ICSI. Recent findings challenging this view compelled us to conduct this study to examine the correlation between AMH levels and quantity/quality of oocytes in IVF/ICSI procedures.
The data were collected retrospectively from the medical records of 320 women between 25-42 years old. The included patients were divided into two groups: the high AMH group (>1.1 ) and the low AMH (=<1.1 ) group. The high AMH group comprised 213 patients, while the low AMH group consisted of 107 patients. Spearman's correlation coefficient and Multinomial logistic regression were computed to assess the relationships between different variables.
Significant positive correlations were detected between AMH level and the number of aspirated follicles (rho=0.741, p<0.001), retrieved oocytes (rho=0.659, p<0.001), M2 oocytes (rho=0.624, p<0.001), grade A embryos (rho=0.419, p<0.001), and grade AB embryos (rho=0.446, p<0.001. In contrast, AMH levels had negative associations with the number and duration of cycles (p<0.05). AMH emerged as a statistically significant independent predictor of the number of M2 oocytes.
Serum AMH level could represent the quantity and quality of oocytes following IVF/ICSI treatments. Future studies should aim to delve deeper into the correlations between AMH levels and both the quality and quantity of embryos. Additionally, it would be beneficial to consider the influence of sperm factors, as well as assess pregnancy rates.
抗苗勒管激素（AMH）作为女性生物学年龄和卵巢储备的标志物，其在预测体外受精/卵胞浆内单精子注射（IVF/ICSI）过程中卵母细胞质量方面的有效性引发了争论。最近的研究结果对这一观点提出了挑战，促使我们开展本研究，以检验IVF/ICSI程序中AMH水平与卵母细胞数量/质量之间的相关性。
回顾性收集320名年龄在25至42岁之间女性的病历资料。纳入的患者分为两组：高AMH组（>1.1）和低AMH组（<=1.1）。高AMH组包括213例患者，低AMH组由107例患者组成。计算Spearman相关系数和多项逻辑回归，以评估不同变量之间的关系。
AMH水平与抽吸卵泡数（rho=0.741，p<0.001）、回收卵母细胞数（rho=0.659，p<0.001）、M2期卵母细胞数（rho=0.624，p<0.001）、A级胚胎数（rho=0.419，p<0.001）和AB级胚胎数（rho=0.446，p<0.001）之间存在显著正相关。相反，AMH水平与周期数和周期持续时间呈负相关（p<0.05）。AMH是M2期卵母细胞数量的统计学显著独立预测因子。
血清AMH水平可代表IVF/ICSI治疗后卵母细胞的数量和质量。未来的研究应旨在更深入地探究AMH水平与胚胎质量和数量之间的相关性。此外，考虑精子因素的影响以及评估妊娠率将是有益的。
