Xiong Yuyuan, Liu Xiaoyu, Wang Yexing
Department of Breast and Thyroid Surgery, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei, China.
Department of General Surgery, Affiliated Hospital of Hubei, Xiangyang Central Hospital, University of Arts and Science, Xiangyang, Hubei, China.
Sci Rep. 2025 Jul 1;15(1):20485. doi: 10.1038/s41598-025-05873-6.
Experiencing breast cancer (BC) has been recognized as a profoundly traumatic event for women, often resulting in psychiatric complications, notably depression. Furthermore, depression can adversely impact the prognosis of BC. The purpose of this study was to determine the specific changes in circulating vitamin D binding protein (VDBP) levels and to assess its clinical significance for diagnosing and predicting depression in BC patients. 168 BC patients, including 83 depressive ones and 85 non-depressive ones, and 60 healthy controls (HCs) were recruited in the present study. 25-hydroxyvitamin D [25(OH)D], calcium, and VDBP in the blood samples were detected. A six-month follow-up study was also conducted for 83 BC patients with depression. Firstly, plasma VDBP levels were significantly increased in BC patients with depression as compared to HCs or BC patients without depression. Secondly, plasma VDBP showed the great discriminatory power for identifying BC patients with depression from those without (area under curve = 0.816). Thirdly plasma VDBP, serum 25(OH)D, and serum glial fibrillary acidic protein (GFAP) levels were significantly associated with the severity of depression in BC patients. Fourthly, the interactive effects between circulating VDBP and GFAP levels had effect on the progression of depression in BC patients. Consequently, plasma VDBP may be a potential biomarker for predicting the depressive disorder risk in BC patients.
经历乳腺癌（BC）已被认为是女性极其痛苦的事件，常导致精神并发症，尤其是抑郁症。此外，抑郁症会对BC的预后产生不利影响。本研究的目的是确定循环维生素D结合蛋白（VDBP）水平的具体变化，并评估其对BC患者抑郁症诊断和预测的临床意义。本研究招募了168例BC患者，包括83例抑郁患者和85例非抑郁患者，以及60例健康对照者（HCs）。检测血样中的25-羟基维生素D [25(OH)D]、钙和VDBP。还对83例患有抑郁症的BC患者进行了为期6个月的随访研究。首先，与HCs或无抑郁症的BC患者相比，患有抑郁症的BC患者血浆VDBP水平显著升高。其次，血浆VDBP对识别有抑郁症和无抑郁症的BC患者具有很大的鉴别能力（曲线下面积=0.816）。第三，血浆VDBP、血清25(OH)D和血清胶质纤维酸性蛋白（GFAP）水平与BC患者抑郁症的严重程度显著相关。第四，循环VDBP和GFAP水平之间的交互作用对BC患者抑郁症的进展有影响。因此，血浆VDBP可能是预测BC患者抑郁症风险的潜在生物标志物。
