Ozawa Yoko, Onozato Noriko, Togawa Haruna, Shimmura Shigeto
Department of Clinical Regenerative Medicine, Fujita Medical Innovation Center Tokyo; Eye Center, Fujita Health University, Haneda Clinic, Tokyo, Japan.
Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan.
Sci Rep. 2025 Jul 1;15(1):21796. doi: 10.1038/s41598-025-06863-4.
Retinal thickness measured using optical coherence tomography (OCT) is a major parameter to evaluate retinal diseases. However, it may be influenced by systemic factors. We retrospectively analyzed OCT images and blood sample data from 266 participants (49.1 ± 10.5 years) including 181 (68.0%) males who underwent medical checkups at Fujita Medical Innovation Center, Tokyo. Those with retinal pathological findings were excluded. Males had thicker retinas in the center and inner circles of Early Treatment Diabetic Retinopathy Study grid (P < 0.01 for all). Mean thicknesses of the superior areas were greater than those of the inferior areas in inner and outer circles (P < 0.01 for both). However, there were eyes with thicker inner inferior areas (72 eyes, 27.1%), which was observed more frequently in males (P = 0.018). Thicker retinas were associated with lower hemoglobin A1c levels in the center (P = 0.012), and inner temporal (P = 0.042) and inferior (P = 0.047) areas; lower creatinine levels in the inner temporal (P = 0.002), superior (P = 0.026), and inferior (P < 0.001) areas; and higher high-density lipoprotein cholesterol levels in the inner nasal (P = 0.029) and inferior (P = 0.029) areas after adjusting for age and sex. These results may be kept in mind in evaluating OCT data during clinical practice and future clinical trials, although further studies are warranted.
使用光学相干断层扫描（OCT）测量的视网膜厚度是评估视网膜疾病的主要参数。然而，它可能会受到全身因素的影响。我们回顾性分析了266名参与者（49.1±10.5岁）的OCT图像和血液样本数据，其中包括181名（68.0%）男性，他们在东京藤田医学创新中心接受了体检。排除有视网膜病理发现的患者。在糖尿病视网膜病变早期治疗研究网格的中心和内圈，男性的视网膜较厚（所有P<0.01）。在内圈和外圈，上部区域的平均厚度大于下部区域（两者P<0.01）。然而，有72只眼睛（27.1%）的内下部区域较厚，在男性中更常见（P=0.018）。视网膜较厚与中心（P=0.012）、颞内侧（P=0.042）和下部（P=0.047）区域较低的糖化血红蛋白水平相关；与颞内侧（P=0.002）、上部（P=0.026）和下部（P<0.001）区域较低的肌酐水平相关；在调整年龄和性别后，与鼻内侧（P=0.029）和下部（P=0.029）区域较高的高密度脂蛋白胆固醇水平相关。在临床实践和未来的临床试验中评估OCT数据时，可能需要牢记这些结果，尽管还需要进一步研究。
