Department of Cardiology, the Xiamen Cardiovascular Hospital of Xiamen University, Xiamen, Fujian, China.
Department of Cardiology, the Xiamen Cardiovascular Hospital of Xiamen University, Xiamen, Fujian, China.
Int Immunopharmacol. 2024 Sep 10;138:112622. doi: 10.1016/j.intimp.2024.112622. Epub 2024 Jul 6.
Dyslipidemia, characterized by higher serum concentrations of low-density lipoprotein cholesterol (LDL-C), very low-density lipoprotein cholesterol (VLDL-C), triglyceride (TG), and lower serum concentrations of high-density lipoprotein cholesterol (HDL-C), is confirmed as a hallmark of cardiovascular diseases (CVD), posing serious risks to the future health of humans. Aside from the role of HDL-C concentrations, the capacity of cholesterol efflux to HDL is being identified as an enssential messurement for the dyslipidemic morbidity. Through inducing the progression of reverse cholesterol transport (RCT), the HDL-related cholesterol efflux plays a vital role in atherosclerotic plaque formation. In addition, increasing results demonstrated that the relationships between cholesterol efflux and cardiovascular events might be influenced by multiple factors, such as atherosclerosis, diabetes, and, inflammatory diseases. These risk factors could affect the intracellular composition of HDL, which might subsqently influence the cholesterol efflux process induced by HDL particle. In the present comprehensive article, we summarize the latest findings which described the modulatory roles of HDL in cardiometabolic disorders and inflammatory related diseases, focusing on its capacity in mediating cholesterol efflux. Moreover, the potential mechanisms whereby HDL regulate the risk of cardiometabolic disorders or inflammatory related diseases, at least partly, via cholesterol efflux pathway, are also well-listed.
血脂异常表现为血清低密度脂蛋白胆固醇（LDL-C）、极低密度脂蛋白胆固醇（VLDL-C）、甘油三酯（TG）浓度升高，高密度脂蛋白胆固醇（HDL-C）浓度降低，这已被确认为心血管疾病（CVD）的标志，对人类未来的健康构成严重威胁。除了 HDL-C 浓度的作用外，胆固醇流出到 HDL 的能力也被认为是血脂异常发病的重要衡量标准。通过诱导胆固醇逆向转运（RCT）的进展，HDL 相关的胆固醇外排在动脉粥样硬化斑块形成中起着至关重要的作用。此外，越来越多的结果表明，胆固醇外排与心血管事件之间的关系可能受到多种因素的影响，如动脉粥样硬化、糖尿病和炎症性疾病。这些危险因素可能会影响 HDL 的细胞内组成，从而影响由 HDL 颗粒诱导的胆固醇外排过程。在本综述文章中，我们总结了最新的发现，描述了 HDL 在代谢性心血管疾病和炎症相关疾病中的调节作用，重点介绍了其介导胆固醇外排的能力。此外，还详细列出了 HDL 通过胆固醇外排途径调节代谢性心血管疾病或炎症相关疾病风险的潜在机制。
