Chen Xiaosheng, Guo Hanbin, Cao Sizhe, Lin Jieming, Huang Peidong, Zhang Wei, Lin Huirong, Li Xinji, Zhang Hui
Department of Urology, Jieyang People's Hospital, Jieyang, 522000, Guangdong, People's Republic of China.
Department of Gastrointestinal-2 and Vascular Surgery, The Second Affiliated Hospital of Shantou University Medical College, Shantou, 515000, Guangdong, People's Republic of China.
Sci Rep. 2025 Jul 1;15(1):20811. doi: 10.1038/s41598-025-08634-7.
Bladder cancer is the most prevalent malignancies in the urinary system. This study was designed to investigate the trends of bladder cancer in China and differences compared with various Socio-demographic index (SDI) regions. Data from the Global Burden of Disease (GBD) 2021 database were utilized to evaluate metrics associated with bladder cancer, including age-standardized incidence rate (ASIR), age-standardized prevalence rate (ASPR), age-standardized mortality rate (ASMR), and age-standardized disability-adjusted life years rate (DALY) (ASDR). All analyses, including joinpoint regression, age-period-cohort, decomposition, spearman correlation, frontier and cross-country inequality, and Bayesian age-period-cohort, were utilized. In 2021, bladder cancer posed a significant health burden in China, with 570,636 total cases, including 463,364 males. The disease burden increased from low to high SDI regions, with China falling in the middle to high-middle SDI range. Apart from China, middle SDI and low-middle SDI regions, the ASIR of all other SDI regions showed a decreasing trend. The ASPR of bladder cancer increase globally, particularly in China and middle SDI region. Meanwhile, the ASMR and ASDR declined in China and all SDI regions. The age-period-cohort analysis showed that period and cohort effects influenced the ASIR and ASPR differently across China and each SDI region. Population growth was the primary driver of increases in these metrics. Projections suggest continued increases in ASIR, ASPR, and ASDR for both genders in China through 2036. The burden of bladder cancer is significant in China and varies across SDI regions, highlighting the link between socioeconomic development and disease burden.
膀胱癌是泌尿系统中最常见的恶性肿瘤。本研究旨在调查中国膀胱癌的发病趋势以及与不同社会人口学指数（SDI）地区的差异。利用全球疾病负担（GBD）2021数据库的数据来评估与膀胱癌相关的指标，包括年龄标准化发病率（ASIR）、年龄标准化患病率（ASPR）、年龄标准化死亡率（ASMR）以及年龄标准化伤残调整生命年率（DALY）（ASDR）。所有分析方法，包括Joinpoint回归、年龄-时期-队列分析、分解分析、Spearman相关性分析、前沿和跨国不平等分析以及贝叶斯年龄-时期-队列分析均被采用。2021年，膀胱癌在中国造成了重大的健康负担，总病例数达570,636例，其中男性463,364例。疾病负担从低SDI地区向高SDI地区递增，中国处于中高SDI范围。除中国、中等SDI和低中等SDI地区外，所有其他SDI地区的ASIR均呈下降趋势。膀胱癌的ASPR在全球范围内上升，尤其是在中国和中等SDI地区。与此同时，中国及所有SDI地区的ASMR和ASDR均有所下降。年龄-时期-队列分析表明，时期和队列效应在中国及每个SDI地区对ASIR和ASPR的影响有所不同。人口增长是这些指标上升的主要驱动因素。预测显示，到2036年中国两性的ASIR、ASPR和ASDR将持续上升。膀胱癌在中国的负担较重，且在不同SDI地区有所差异，凸显了社会经济发展与疾病负担之间的联系。
