Yang Jingxian, Chen Yongjie, Wan Jun, Li Feina, Yang Xinyu, Shen Binger, Li Na, Didi Jiajia, Zhou Lijiao, Zhang Yu
Center for Evidence-based Medicine, Affiliated Hospital of Chengdu University, Chengdu, Sichuan, China.
Department of critical care medicine, Affiliated Hospital of Chengdu University, Chengdu, Sichuan, China.
Sci Rep. 2025 Jul 1;15(1):21150. doi: 10.1038/s41598-025-07327-5.
Stroke poses a significant mortality threat and frequently results in survivors experiencing varying degrees of residual disability. The objective of this meta-analysis was to elucidate the association between C-reactive protein-to-albumin ratio (CAR) and prognosis in patients with stroke. We searched the databases of PubMed, Embase, the Cochrane Library, and CNKI for relevant studies up to 26th January 2024. The quality of the included studies was evaluated using the Newcastle Ottawa Quality Assessment Scale (NOS). Pooled odds ratios (OR) with 95% confidence intervals (CI) were calculated for the association between CAR and poor functional outcomes and mortality. A total of nine studies with 2954 patients were included. The pooled results demonstrated that elevated CAR was associated with poor functional outcomes in patients with stroke (OR: 2.24; 95% CI: 1.81-2.78; P < 0.00001). Similarly, elevated CAR was associated with mortality in patients with stroke (OR: 2.11; 95% CI: 1.51-2.94; P < 0.0001). CAR has prognostic value for poor functional outcomes and mortality in patients with stroke.
中风构成了重大的死亡威胁，并且经常导致幸存者出现不同程度的残余残疾。本荟萃分析的目的是阐明C反应蛋白与白蛋白比值（CAR）与中风患者预后之间的关联。我们检索了截至2024年1月26日的PubMed、Embase、Cochrane图书馆和中国知网数据库中的相关研究。使用纽卡斯尔渥太华质量评估量表（NOS）评估纳入研究的质量。计算CAR与不良功能结局和死亡率之间关联的合并比值比（OR）及95%置信区间（CI）。共纳入9项研究，涉及2954例患者。汇总结果表明，CAR升高与中风患者的不良功能结局相关（OR：2.24；95%CI：1.81-2.78；P<0.00001）。同样，CAR升高与中风患者的死亡率相关（OR：2.11；95%CI：1.51-2.94；P<0.0001）。CAR对中风患者的不良功能结局和死亡率具有预后价值。
