Gupta Himanshu, Barde Pradip V, Singh Mrigendra Pal, Bharti Praveen K, Nitika Nitika
Department of Biotechnology, Institute of Applied Sciences & Humanities, GLA University, Mathura, India.
ICMR-National Institute of Virology (Central Zone), Jabalpur, India.
Commun Med (Lond). 2025 Jul 1;5(1):254. doi: 10.1038/s43856-025-00968-7.
Outbreaks of arboviruses have become one of the major and consistent health burdens in India. With no effective vaccines or antivirals, it is challenging to control the exponential increase in cases of arboviral diseases. Accurate assessment of cases, timely and accurate diagnosis, treatment, tracking fatalities, surveillance of vectors, adopting integrated vector management policies, real-time genomic surveillance, and relating these to symptoms and tracking transmission are essential for keeping the emergence of arboviruses in check. This comprehensive review explores current literature and potential curative perspectives, focusing on major arboviruses, including dengue, chikungunya, Japanese encephalitis, Zika, Kyasanur forest disease, and Crimean-Congo haemorrhagic fever, and advancements in diagnosis, treatment protocols, supportive care, and the development of preventive measures. We aim to provide a thorough understanding of their epidemiology and impact in India, while identifying research and policy gaps that will enable policymakers to design effective strategies for managing the impact of arboviral diseases.
虫媒病毒的爆发已成为印度主要且持续存在的健康负担之一。由于没有有效的疫苗或抗病毒药物，控制虫媒病毒疾病病例的指数级增长具有挑战性。准确评估病例、及时准确诊断、治疗、追踪死亡病例、监测病媒、采用综合病媒管理政策、实时基因组监测，并将这些与症状相关联以及追踪传播情况，对于控制虫媒病毒的出现至关重要。这篇全面综述探讨了当前文献和潜在的治疗前景，重点关注主要的虫媒病毒，包括登革热、基孔肯雅热、日本脑炎、寨卡病毒、凯萨努尔森林病和克里米亚-刚果出血热，以及诊断、治疗方案、支持性护理方面的进展和预防措施的开发。我们旨在全面了解它们在印度的流行病学和影响，同时找出研究和政策差距，以便政策制定者能够设计有效的策略来管理虫媒病毒疾病的影响。
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