Chen Yumei, Yu Denghua, Zhu Dongwei, Muthusamy Selvaraj, Deshpande Mangirish, Kiruthiga Natarajan, Theivendren Panneerselvam, Rajalakshmi Kanagaraj, Wu Siyi, Zhu Chengdong
Department of Laboratory Medicine, Yizheng People's Hospital, Yangzhou 211400, PR China.
Department of Immunology, Jiangsu Key Laboratory of Laboratory Medicine, School of Medicine, School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013, PR China.
Pathol Res Pract. 2025 Aug;272:156092. doi: 10.1016/j.prp.2025.156092. Epub 2025 Jun 24.
Cervical cancer stands as one of the major causes which result in death due to cancer in female patients all over the world. The treatment measures such as chemotherapy and radiations are still producing unfavourable side effects that are also limiting their efficacies in treatment. The capability of alkaloids and flavonoid to target cellular mechanisms that lead to the development of cancer cells has been investigated through research studies. This review study evaluates the mechanism of action of alkaloids in combination with flavonoids derived in various plant species to prevent the progression of cervical cancer. The bioactive constituents exhibit appealing therapeutic effects as they induce apoptosis and reduce inflammation and neutralize oxidative stress. Berberine and sanguinarine alkaloids as well as quercetin and kaempferol flavonoid exhibit cervical cancer cells-damaging apoptotic effects and inhibit inflammation by regulating inflammatory cytokines and strengthening antioxidant defense. The capability of these compounds to modulate PI3K/Akt and NF-kB and MAPK and p53 signaling pathways implies that they can be developed into non-toxic therapeutic options to be used in cases of cervical cancer. Mechanistic insights and clinical evidence of the use of alkaloids and flavonoids in the management of cervical cancer are reviewed and their suitability as natural products in cancer therapeutic intervention considered.
宫颈癌是全球女性癌症死亡的主要原因之一。化疗和放疗等治疗措施仍会产生不良副作用，这也限制了它们的治疗效果。通过研究，人们已经对生物碱和黄酮类化合物靶向导致癌细胞发展的细胞机制的能力进行了调查。本综述研究评估了生物碱与各种植物中提取的黄酮类化合物联合作用预防宫颈癌进展的作用机制。这些生物活性成分具有诱人的治疗效果，因为它们能诱导细胞凋亡、减轻炎症并中和氧化应激。黄连素和血根碱生物碱以及槲皮素和山奈酚黄酮类化合物对宫颈癌细胞具有破坏凋亡的作用，并通过调节炎症细胞因子和加强抗氧化防御来抑制炎症。这些化合物调节PI3K/Akt、NF-κB、MAPK和p53信号通路的能力表明，它们可以被开发成无毒治疗选择，用于宫颈癌的治疗。本文综述了生物碱和黄酮类化合物在宫颈癌治疗中的作用机制及临床证据，并考虑了它们作为天然产物在癌症治疗干预中的适用性。
