接受新辅助化疗的胃癌患者中性粒细胞与淋巴细胞比值和血小板与淋巴细胞比值与预后的相关性：一项荟萃分析

Correlation between neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio with prognosis in gastric cancer patients undergoing neoadjuvant chemotherapy: a meta-analysis.

作者信息

Yang Shuang, Li Zhuoyang, Wang Tianhong, Zou Congcong, Wang Siman, Deng Shuang, Hua Yusi

机构信息

Department of Anesthesiology, West China Hospital, School of Nursing, Sichuan University/ West China Sichuan University, Chengdu, Sichuan Province, 610041, China.

School of Medicine, Wuhan University of Science and Technology, Wuhan, 430065, China.

出版信息

BMC Gastroenterol. 2025 Jul 1;25(1):445. doi: 10.1186/s12876-025-04056-x.

DOI:10.1186/s12876-025-04056-x

PMID:40597685

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12211959/

Abstract

INTRODUCTION

Inflammatory markers such as the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are associated with poorer prognosis of gastric cancer (GC) patients and may guide treatment decisions. This meta-analysis aims to evaluate the impact of NLR and PLR on the prognosis of GC patients undergoing neoadjuvant chemotherapy (NAC).

METHODS

Cochrane, Embase, PubMed and Web of science were searched for studies up to November 30, 2024. Meta-analysis was conducted to evaluate the pooled effect. Sensitivity analysis was conducted by removing a different study each time. Publication bias was assessed by Egger’s test and Begg’s test to evaluate quantitatively.

RESULTS

A total of 16 studies were included in this meta-analysis from 3,094 studies. Pre-NAC high NLR level was associated with poorer overall survival outcomes (HR = 1.96, 95% CI 1.21–3.20). Similarly, post-NAC high NLR was also correlated with worse overall survival outcomes (HR = 1.69, 95% CI 1.04–2.76). However, pre-NAC PLR and post-NAC PLR did not appear to exhibit a significant correlation with the prognosis of gastric cancer patients following NAC.

CONCLUSION

NLR is emerging as a potential prognostic indicator for gastric cancer, particularly in patients receiving NAC. Elevated NLR levels both before and after NAC are associated with poorer overall survival outcomes in gastric cancer patients.

SUPPLEMENTARY INFORMATION

The online version contains supplementary material available at 10.1186/s12876-025-04056-x.

摘要

引言

中性粒细胞与淋巴细胞比值（NLR）和血小板与淋巴细胞比值（PLR）等炎症标志物与胃癌（GC）患者较差的预后相关，可能指导治疗决策。本荟萃分析旨在评估NLR和PLR对接受新辅助化疗（NAC）的GC患者预后的影响。

方法

检索Cochrane、Embase、PubMed和Web of science截至2024年11月30日的研究。进行荟萃分析以评估合并效应。每次去除一项不同的研究进行敏感性分析。通过Egger检验和Begg检验评估发表偏倚以进行定量评估。

结果

本荟萃分析共纳入了来自3094项研究中的16项研究。新辅助化疗前高NLR水平与较差的总生存结局相关（HR = 1.96，95% CI 1.21 - 3.20）。同样，新辅助化疗后高NLR也与较差的总生存结局相关（HR = 1.69，95% CI 1.04 - 2.76）。然而，新辅助化疗前PLR和新辅助化疗后PLR似乎与接受NAC后的胃癌患者预后无显著相关性。