Qiu Yawei, Guo Lin, Pan Hongyan, He Huaqiu, Li Qiang
Department of Endocrinology and Metabolism, Shenzhen University General Hospital, No. 1298, Xueyuan Avenue, Nanshan District, Shenzhen, 518055, China.
BMC Endocr Disord. 2025 Jul 1;25(1):155. doi: 10.1186/s12902-025-01969-2.
There are few studies comparing Type 3 autoimmune polyendocrine syndromes (APS) with isolated type 1 diabetes mellitus (T1DM), latent autoimmune diabetes in youth (LADY), and latent autoimmune diabetes in adults (LADA) in the Chinese population. This study aims to report the clinical and serological characteristics of Chinese patients with Type 3 APS, isolated T1DM, LADY and LADA, and to make comparisons.
This study retrospectively analyzed the clinical and serological characteristics of hospitalized patients with Type 3 APS, T1DM, LADY and LADA who were admitted to our center.
A total of 69 patients were included in this study, comprising 18 with Type 3 APS, 20 with T1DM, and 31 with LADY/LADA. The majority of Type 3 APS patients were female, whereas T1DM and LADY/LADA groups had a higher proportion of males. The median age and onset age of diabetes in the Type 3 APS group were 35.50 (31.00, 52.50) years and 30.50 (26.75, 47.25) years, respectively. Diabetes and autoimmune thyroid disease (AITD) in Type 3 APS patients may occur simultaneously or several years apart. The levels of GADAb and thyroid autoantibodies in Type 3 APS patients were often higher.
Type 3 APS exhibits differences when compared to isolated T1DM and LADY/LADA. For patients with TIDM or LADY/LADA, especially female patients, those over 30 years old or with high-titer GADAb, attention should be paid to screening for APS 3, including the detection of thyroid autoantibodies. Patients suspected or confirmed to have Type 3 APS need long-term follow-up.
Not applicable.
在中国人群中，比较3型自身免疫性多内分泌综合征（APS）与1型糖尿病（T1DM）、青年隐匿性自身免疫性糖尿病（LADY）和成人隐匿性自身免疫性糖尿病（LADA）的研究较少。本研究旨在报告中国3型APS、孤立性T1DM、LADY和LADA患者的临床和血清学特征，并进行比较。
本研究回顾性分析了我院中心收治的3型APS、T1DM、LADY和LADA住院患者的临床和血清学特征。
本研究共纳入69例患者，其中18例为3型APS，20例为T1DM，31例为LADY/LADA。3型APS患者以女性居多，而T1DM和LADY/LADA组男性比例较高。3型APS组的糖尿病中位年龄和发病年龄分别为35.50（31.00，52.50）岁和30.50（26.75，47.25）岁。3型APS患者的糖尿病和自身免疫性甲状腺疾病（AITD）可能同时发生，也可能相隔数年。3型APS患者的GADAb和甲状腺自身抗体水平通常较高。
3型APS与孤立性T1DM和LADY/LADA相比存在差异。对于TIDM或LADY/LADA患者，尤其是女性患者、30岁以上患者或GADAb滴度高的患者，应注意筛查3型APS，包括检测甲状腺自身抗体。疑似或确诊为3型APS的患者需要长期随访。
不适用。
