Urakawa Hiroshi, Ikuta Kunihiro, Sakai Tomohisa, Koike Hiroshi, Fujito Takeo, Nishida Yoshihiro, Imagama Shiro
Department of Advanced Medicine, Nagoya University Hospital, 65 Tsurumai, Showa-ku, Nagoya, 466-8560, Japan.
Department of Orthopaedic Surgery, Nagoya University Hospital, Nagoya, Japan.
BMC Musculoskelet Disord. 2025 Jul 1;26(1):581. doi: 10.1186/s12891-025-08895-3.
BACKGROUND: Nodular fasciitis (NF) shrinks spontaneously; however, few reports have focused on its self-regression. This study investigated NF shrinkage. METHODS: We retrospectively reviewed 55 patients with NF who visited Nagoya University Hospital. Twenty-three patients were followed-up and evaluated for shrinkage. Factors affecting the occurrence of deep layers and ≥ 50% tumor volume shrinkage were investigated. The proportion of patients who achieved ≥ 50% tumor volume shrinkage, time to ≥ 50% tumor volume shrinkage, and tumor volume compared with baseline at the last follow-up were assessed. RESULTS: The presence of deep layers was significantly associated with longer symptom duration and more frequent biopsies. The proportion of patients who achieved ≥ 50% tumor volume shrinkage, time to ≥ 50% tumor volume shrinkage, and tumor volume compared to baseline at the last follow-up were 17 of 23 patients (74%), median 104 days (19–973)days, and median 24% (7–99%), respectively. Shorter duration of symptoms was significantly associated with ≥ 50% tumor volume shrinkage. CONCLUSION: Approximately three-quarters of the patients demonstrated ≥ 50% tumor volume shrinkage, suggesting that wait-and-see concept was acceptable for NF. The better understanding of NF shrinkage showed that proper follow-up is necessary for patients with NF.
背景：结节性筋膜炎（NF）可自发缩小；然而，很少有报告关注其自行消退情况。本研究调查了NF的缩小情况。 方法：我们回顾性分析了55例就诊于名古屋大学医院的NF患者。对其中23例患者进行随访并评估其缩小情况。研究影响深层出现及肿瘤体积缩小≥50%的因素。评估达到肿瘤体积缩小≥50%的患者比例、达到肿瘤体积缩小≥50%的时间以及末次随访时与基线相比的肿瘤体积。 结果：深层的存在与症状持续时间较长及活检频率较高显著相关。23例患者中达到肿瘤体积缩小≥50%的患者比例、达到肿瘤体积缩小≥50%的时间以及末次随访时与基线相比的肿瘤体积分别为17例（74%）、中位数104天（19 - 973天）和中位数24%（7 - 99%）。症状持续时间较短与肿瘤体积缩小≥50%显著相关。 结论：约四分之三的患者肿瘤体积缩小≥50%，这表明对于NF采取观察等待的策略是可以接受的。对NF缩小情况的更好理解表明，对NF患者进行适当的随访是必要的。
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