Vindis Kinga, Babeș Katalin
Doctoral School of Biomedical Sciences, Faculty of Medicine and Pharmacy, University of Oradea, Oradea, Romania.
Department of Psycho Neuroscience and Recovery, Faculty of Medicine and Pharmacy, University of Oradea, Oradea, Romania.
J Med Life. 2025 May;18(5):487-493. doi: 10.25122/jml-2025-0080.
Dyspnea, regardless of cause, is frequently associated with neuromuscular disorders. Many adults with chronic dyspnea associated with neuromuscular disorders have associated heart or lung disease. This study aimed to identify the association between chronic dyspnea of different etiologies and musculoskeletal disorders identified at presentation to establish a rehabilitation program. This prospective study was carried out in the Medical Rehabilitation Department of Dr. Pop Mircea Municipal Hospital in Marghita and included 163 consecutive patients with chronic dyspnea of different etiologies. The analysis showed no significant difference in the risk of musculoskeletal disorders between men and women (RR = 1.0090). Similarly, we found no significantly increased risk of musculoskeletal disorders in obese individuals compared to overweight (RR = 1.1223; 95% CI, 0.9648-1.3055; z = 1.495; = 0.135) or normal-weight individuals (RR = 1.0399; 95% CI, 0.8997-1.2019; z = 0.529; = 0.597). Overweight individuals also did not show a significantly increased risk compared to normal weight (RR = 1.0793; 95% CI, 0.9132-1.2756; z = 0.895; = 0.371). The risk of developing head protrusion was 1.5 times higher in obese vs. normal-weight (RR = 1.4943; 95% CI, 1.0426-2.1416; z = 2.187; = 0.029), and 1.4 times higher in overweight vs. normal-weight individuals (RR = 1.3565; 95% CI, 0.9153-2.0103; z = 1.519; = 0.129). No significant difference in this risk was found between obese and overweight groups (RR = 1.1015; 95% CI, 0.8494-1.4286; z = 0.729; = 0.466). As for thoracic kyphosis, we determined a 2.1-fold higher risk of occurrence in obese patients compared to normal-weight (RR = 2.1250; 95% CI, 1.2403-3.6408, z = 2.744; = 0.006) and 2-fold higher in overweight compared to normal-weight (RR = 2.0357; 95% CI, 1.1812-3.5085; z = 2.560; = 0.011). The study highlights the correlations between dyspnea, musculoskeletal status, and variations by gender and age, suggesting directions for personalized therapeutic interventions.
呼吸困难，无论病因如何，都常与神经肌肉疾病相关。许多患有与神经肌肉疾病相关的慢性呼吸困难的成年人同时患有心脏或肺部疾病。本研究旨在确定不同病因的慢性呼吸困难与就诊时发现的肌肉骨骼疾病之间的关联，以制定康复计划。这项前瞻性研究在马尔吉塔市波普·米尔恰市立医院的医学康复科进行，纳入了163例不同病因的慢性呼吸困难患者。分析显示，男性和女性患肌肉骨骼疾病的风险无显著差异（相对风险 = 1.0090）。同样，我们发现肥胖个体与超重个体（相对风险 = 1.1223；95%置信区间，0.9648 - 1.3055；z = 1.495；P = 0.135）或正常体重个体（相对风险 = 1.0399；95%置信区间，0.8997 - 1.2019；z = 0.529；P = 0.597）相比，患肌肉骨骼疾病的风险没有显著增加。超重个体与正常体重个体相比，风险也没有显著增加（相对风险 = 1.0793；95%置信区间，0.9132 - 1.2756；z = 0.895；P = 0.371）。肥胖个体出现头部前突的风险是正常体重个体的1.5倍（相对风险 = 1.4943；95%置信区间，1.0426 - 2.1416；z = 2.187；P = 0.029），超重个体是正常体重个体的1.4倍（相对风险 = 1.3565；95%置信区间，0.9153 - 2.0103；z = 1.519；P = 0.129）。肥胖组和超重组在这一风险上没有显著差异（相对风险 = 1.1015；95%置信区间，0.8494 - 1.4286；z = 0.729；P = 0.466）。至于胸椎后凸，我们确定肥胖患者发生的风险是正常体重患者的2.1倍（相对风险 = 2.1250；95%置信区间，1.2403 - 3.6408，z = 2.744；P = 0.006），超重患者是正常体重患者的2倍（相对风险 = 2.0357；95%置信区间，1.1812 - 3.5085；z = 2.560；P = 0.011）。该研究强调了呼吸困难、肌肉骨骼状况以及性别和年龄差异之间的相关性，为个性化治疗干预提供了方向。
