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一例罕见的宫颈肾外威尔姆斯瘤：诊断挑战与保留生育功能的治疗

A rare case of cervical extrarenal Wilms tumor: diagnostic challenges and fertility-sparing management.

作者信息

Turker Saricoban Cansu, Yavuz Ayse, Arslan Yagmur, Gokbasi Ozge, Acikgoz Abdullah Serdar, Bese Tevfik Tugan, Ilvan Sennur

机构信息

Department of Pathology, Istanbul University-Cerrahpasa, Cerrahpasa Faculty of Medicine, Istanbul, Turkey.

Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Istanbul University-Cerrahpasa, Cerrahpasa Faculty of Medicine, Istanbul, Turkey.

出版信息

Gynecol Oncol Rep. 2025 Jun 15;60:101787. doi: 10.1016/j.gore.2025.101787. eCollection 2025 Aug.

DOI:10.1016/j.gore.2025.101787
PMID:40600148
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12209980/
Abstract

OBJECTIVES

Extrarenal Wilms tumor (ERWT) is an exceedingly rare neoplasm, particularly when located in the uterine cervix.

METHODS

We report the case of a 26-year-old nulliparous female who presented with a large cervical mass and underwent clinical, radiological, and pathological evaluation.

RESULTS

Initial biopsy revealed biphasic morphology with atypical epithelial and stromal components, while the absence of a blastemal component posed a diagnostic challenge. Subsequent excision demonstrated classic triphasic morphology, confirming the diagnosis of ERWT. The patient underwent fertility-preserving surgery followed by adjuvant chemotherapy and remains disease-free at one-year follow-up.

CONCLUSIONS

This case highlights the importance of considering ERWT in the differential diagnosis of cervical tumors and demonstrates that standard renal Wilms tumor treatment protocols can be effectively adapted to extrarenal locations.

摘要

目的

肾外Wilms瘤（ERWT）是一种极其罕见的肿瘤，尤其是位于子宫颈时。

方法

我们报告一例26岁未生育女性病例，该患者出现巨大宫颈肿物，并接受了临床、影像学和病理评估。

结果

最初的活检显示具有非典型上皮和间质成分的双相形态，而未发现胚芽成分给诊断带来了挑战。随后的切除显示出典型的三相形态，确诊为ERWT。该患者接受了保留生育功能的手术，随后进行辅助化疗，在一年的随访中仍无疾病。

结论

该病例强调了在宫颈肿瘤鉴别诊断中考虑ERWT的重要性，并表明标准的肾Wilms瘤治疗方案可有效应用于肾外部位。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38e9/12209980/2af31d85fd76/gr10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38e9/12209980/d98ed8e3d8df/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38e9/12209980/773ada58a454/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38e9/12209980/4c5faa23b155/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38e9/12209980/b5a85e28c2d9/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38e9/12209980/0f52bdcf9493/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38e9/12209980/62c491823bfe/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38e9/12209980/18d4c22766c9/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38e9/12209980/c9fbd7cf323a/gr9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38e9/12209980/2af31d85fd76/gr10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38e9/12209980/d98ed8e3d8df/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38e9/12209980/773ada58a454/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38e9/12209980/4c5faa23b155/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38e9/12209980/b5a85e28c2d9/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38e9/12209980/0f52bdcf9493/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38e9/12209980/62c491823bfe/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38e9/12209980/18d4c22766c9/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38e9/12209980/c9fbd7cf323a/gr9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38e9/12209980/2af31d85fd76/gr10.jpg

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