Sritharan Sruthi, Sivalingam Nageswaran
Department of Biotechnology, School of Bioengineering, College of Engineering and Technology, Faculty of Engineering and Technology, SRM Institute of Science and Technology, Kattankulathur, Chengalpattu District, Tamil Nadu, 603203, India.
Arch Toxicol. 2025 Jul 2. doi: 10.1007/s00204-025-04112-1.
The gradual rise in global cancer rates every year instills the need for a reliable therapeutic strategy. Chemotherapy alone or in combination with surgery, radiation, or adjuvant therapy is still the preferred treatment option for a wide range of cancers. Doxorubicin (dox) is an extensively used chemotherapeutic anthracycline for combating a broad range of solid and soft-tissue tumors. However, dox therapy is often associated with undesirable side effects, mainly cardiotoxicity, limiting its clinical application. Over the years, many strategies have been developed to overcome these toxicities and improve the drug's therapeutic potential. This review is focused on discussing the recent investigations into natural compounds, nanoformulations, miRNAs, and physical exercise in protecting against dox-mediated cardiotoxicity, hepatotoxicity, nephrotoxicity, and neurotoxicity.
全球癌症发病率逐年逐渐上升，这凸显了对可靠治疗策略的需求。单独化疗或与手术、放疗或辅助治疗联合使用，仍然是多种癌症的首选治疗方案。阿霉素（dox）是一种广泛使用的化疗蒽环类药物，用于对抗多种实体和软组织肿瘤。然而，阿霉素治疗常常伴有不良副作用，主要是心脏毒性，这限制了其临床应用。多年来，人们已开发出许多策略来克服这些毒性并提高该药物的治疗潜力。本综述重点讨论了关于天然化合物、纳米制剂、微小RNA以及体育锻炼在预防阿霉素介导的心脏毒性、肝毒性、肾毒性和神经毒性方面的最新研究。
